{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:K2M7XHC5QC32NZCAUCD5CQACXX","short_pith_number":"pith:K2M7XHC5","schema_version":"1.0","canonical_sha256":"5699fb9c5d80b7a6e440a087d14002bddb3c24c9eaab99dcf6e300aa532ee10b","source":{"kind":"arxiv","id":"1704.06773","version":2},"attestation_state":"computed","paper":{"title":"Reaching to a small target: entropic barriers and rates of specific binding of polymer to substrate","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"Eugene M. Terentjev, Samuel Bell","submitted_at":"2017-04-22T09:33:15Z","abstract_excerpt":"This paper considers a broadly biologically relevant question of a chain (such as a protein) binding to a sequence of receptors with matching multiple ligands distributed along the chain. This binding is critical in cell adhesion events, and in protein self-assembly. Using a mean field approximation of polymer dynamics, we first calculate the characteristic binding time for a tethered ligand reaching for a specific binding site on the surface. This time is determined by two separate entropic effects: an entropic barrier for the chain to be stretched sufficiently to reach the distant target, an"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1704.06773","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2017-04-22T09:33:15Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"71c7451ece362fe8949412337992cebd103c631213858c6a17bf6e3c7ca31de2","abstract_canon_sha256":"cf2e4a75a2d2a4774c4a0b27d4233879d8318059016236a0ac9688c80e86703f"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:29:30.699850Z","signature_b64":"MtbQTYQkBjoZlzn7929wYt81fgAQJyEWUmAKwmB88fC4h8VxGndvRnTy9bPxc41OA5yBDzMGrusiZXoVVvIwBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5699fb9c5d80b7a6e440a087d14002bddb3c24c9eaab99dcf6e300aa532ee10b","last_reissued_at":"2026-05-18T00:29:30.699165Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:29:30.699165Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Reaching to a small target: entropic barriers and rates of specific binding of polymer to substrate","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.soft","authors_text":"Eugene M. Terentjev, Samuel Bell","submitted_at":"2017-04-22T09:33:15Z","abstract_excerpt":"This paper considers a broadly biologically relevant question of a chain (such as a protein) binding to a sequence of receptors with matching multiple ligands distributed along the chain. This binding is critical in cell adhesion events, and in protein self-assembly. Using a mean field approximation of polymer dynamics, we first calculate the characteristic binding time for a tethered ligand reaching for a specific binding site on the surface. This time is determined by two separate entropic effects: an entropic barrier for the chain to be stretched sufficiently to reach the distant target, an"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.06773","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1704.06773","created_at":"2026-05-18T00:29:30.699263+00:00"},{"alias_kind":"arxiv_version","alias_value":"1704.06773v2","created_at":"2026-05-18T00:29:30.699263+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.06773","created_at":"2026-05-18T00:29:30.699263+00:00"},{"alias_kind":"pith_short_12","alias_value":"K2M7XHC5QC32","created_at":"2026-05-18T12:31:24.725408+00:00"},{"alias_kind":"pith_short_16","alias_value":"K2M7XHC5QC32NZCA","created_at":"2026-05-18T12:31:24.725408+00:00"},{"alias_kind":"pith_short_8","alias_value":"K2M7XHC5","created_at":"2026-05-18T12:31:24.725408+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX","json":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX.json","graph_json":"https://pith.science/api/pith-number/K2M7XHC5QC32NZCAUCD5CQACXX/graph.json","events_json":"https://pith.science/api/pith-number/K2M7XHC5QC32NZCAUCD5CQACXX/events.json","paper":"https://pith.science/paper/K2M7XHC5"},"agent_actions":{"view_html":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX","download_json":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX.json","view_paper":"https://pith.science/paper/K2M7XHC5","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1704.06773&json=true","fetch_graph":"https://pith.science/api/pith-number/K2M7XHC5QC32NZCAUCD5CQACXX/graph.json","fetch_events":"https://pith.science/api/pith-number/K2M7XHC5QC32NZCAUCD5CQACXX/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX/action/timestamp_anchor","attest_storage":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX/action/storage_attestation","attest_author":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX/action/author_attestation","sign_citation":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX/action/citation_signature","submit_replication":"https://pith.science/pith/K2M7XHC5QC32NZCAUCD5CQACXX/action/replication_record"}},"created_at":"2026-05-18T00:29:30.699263+00:00","updated_at":"2026-05-18T00:29:30.699263+00:00"}