{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2023:KNYCBVYHZLDCHHVIPSGHKR3YCT","short_pith_number":"pith:KNYCBVYH","schema_version":"1.0","canonical_sha256":"537020d707cac6239ea87c8c75477814fcdd9a54a0fd41d29bd355c9a2411ea7","source":{"kind":"arxiv","id":"2312.11270","version":3},"attestation_state":"computed","paper":{"title":"Modelling the Lymphatic Metastatic Progression Pathways of OPSCC from Multi-Institutional Datasets","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Adrian Schubert, Bertrand Pouymayou, Dorothea Barbatei, Jan Unkelbach, Jean-Marc Hoffmann, Lauence Bauwens, Matthias Dettmer, Olgun Elicin, Panagiotis Balermpas, Philippe Zrounba, Roland Giger, Roman Ludwig, Sandrine Werlen, Vincent Gr\\'egoire","submitted_at":"2023-12-18T15:14:40Z","abstract_excerpt":"The elective clinical target volume (CTV-N) in oropharyngeal squamous cell carcinoma (OPSCC) is currently based mostly on the prevalence of lymph node metastases in different lymph node levels (LNLs) for a given primary tumor location. We present a probabilistic model for ipsilateral lymphatic spread that can quantify the microscopic nodal involvement risk based on an individual patient's T-category and clinical involvement of LNLs at diagnosis. We extend a previously published hidden Markov model (HMM), which models the LNLs (I, II, III, IV, V, and VII) as hidden binary random variables (RVs)"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2312.11270","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"physics.med-ph","submitted_at":"2023-12-18T15:14:40Z","cross_cats_sorted":[],"title_canon_sha256":"87f3a96883fa19c160a01fa9b1597ad1b2d1efd0ec397d38b17f4317532e9ff2","abstract_canon_sha256":"c9062360461995811997e11e23a7ebfcb603398f5fd7c413aa8a4b1363f01702"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:26:42.374000Z","signature_b64":"bbSzmDTiYatU3V0fbUF3hhPguzR4Akut4S86wyoD8dgSm4vVQHlCrjvNJngiOYsdwZcT90VQY7GMdoF47OqfCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"537020d707cac6239ea87c8c75477814fcdd9a54a0fd41d29bd355c9a2411ea7","last_reissued_at":"2026-07-05T07:26:42.373553Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:26:42.373553Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Modelling the Lymphatic Metastatic Progression Pathways of OPSCC from Multi-Institutional Datasets","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Adrian Schubert, Bertrand Pouymayou, Dorothea Barbatei, Jan Unkelbach, Jean-Marc Hoffmann, Lauence Bauwens, Matthias Dettmer, Olgun Elicin, Panagiotis Balermpas, Philippe Zrounba, Roland Giger, Roman Ludwig, Sandrine Werlen, Vincent Gr\\'egoire","submitted_at":"2023-12-18T15:14:40Z","abstract_excerpt":"The elective clinical target volume (CTV-N) in oropharyngeal squamous cell carcinoma (OPSCC) is currently based mostly on the prevalence of lymph node metastases in different lymph node levels (LNLs) for a given primary tumor location. We present a probabilistic model for ipsilateral lymphatic spread that can quantify the microscopic nodal involvement risk based on an individual patient's T-category and clinical involvement of LNLs at diagnosis. We extend a previously published hidden Markov model (HMM), which models the LNLs (I, II, III, IV, V, and VII) as hidden binary random variables (RVs)"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2312.11270","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2312.11270/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2312.11270","created_at":"2026-07-05T07:26:42.373604+00:00"},{"alias_kind":"arxiv_version","alias_value":"2312.11270v3","created_at":"2026-07-05T07:26:42.373604+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2312.11270","created_at":"2026-07-05T07:26:42.373604+00:00"},{"alias_kind":"pith_short_12","alias_value":"KNYCBVYHZLDC","created_at":"2026-07-05T07:26:42.373604+00:00"},{"alias_kind":"pith_short_16","alias_value":"KNYCBVYHZLDCHHVI","created_at":"2026-07-05T07:26:42.373604+00:00"},{"alias_kind":"pith_short_8","alias_value":"KNYCBVYH","created_at":"2026-07-05T07:26:42.373604+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT","json":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT.json","graph_json":"https://pith.science/api/pith-number/KNYCBVYHZLDCHHVIPSGHKR3YCT/graph.json","events_json":"https://pith.science/api/pith-number/KNYCBVYHZLDCHHVIPSGHKR3YCT/events.json","paper":"https://pith.science/paper/KNYCBVYH"},"agent_actions":{"view_html":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT","download_json":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT.json","view_paper":"https://pith.science/paper/KNYCBVYH","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2312.11270&json=true","fetch_graph":"https://pith.science/api/pith-number/KNYCBVYHZLDCHHVIPSGHKR3YCT/graph.json","fetch_events":"https://pith.science/api/pith-number/KNYCBVYHZLDCHHVIPSGHKR3YCT/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT/action/timestamp_anchor","attest_storage":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT/action/storage_attestation","attest_author":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT/action/author_attestation","sign_citation":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT/action/citation_signature","submit_replication":"https://pith.science/pith/KNYCBVYHZLDCHHVIPSGHKR3YCT/action/replication_record"}},"created_at":"2026-07-05T07:26:42.373604+00:00","updated_at":"2026-07-05T07:26:42.373604+00:00"}