{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:KOOPMDAX7U7XDYSC6YLWCP2WX5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"aec7cc5623ef1459a768eeed3df0b80cf2b6104839f696ef94bb7503d6a06d85","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2012-07-29T15:16:07Z","title_canon_sha256":"c73cb2c9893ae1efc3e97064d7292633a354b493f7b4f977764e1c7d57c7ba0e"},"schema_version":"1.0","source":{"id":"1207.6781","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1207.6781","created_at":"2026-05-18T00:37:02Z"},{"alias_kind":"arxiv_version","alias_value":"1207.6781v3","created_at":"2026-05-18T00:37:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1207.6781","created_at":"2026-05-18T00:37:02Z"},{"alias_kind":"pith_short_12","alias_value":"KOOPMDAX7U7X","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_16","alias_value":"KOOPMDAX7U7XDYSC","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_8","alias_value":"KOOPMDAX","created_at":"2026-05-18T12:27:11Z"}],"graph_snapshots":[{"event_id":"sha256:1ec7ae20a2cab4a44fbfaa69cbd5b28cec30b248df20a1e89c84807aada55f84","target":"graph","created_at":"2026-05-18T00:37:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We present force-clamp data on the collapse of ubiquitin polyproteins in response to a quench in the force. These nonequilibrium trajectories are analyzed using a general method based on a diffusive assumption of the end-to-end length to reconstruct a downhill free energy profile at 5pN and an energy plateau at 10pN with a slow diffusion coefficient on the order of~100nm^2/s. The shape of the free energy and its linear scaling with the protein length give validity to a physical model for the collapse. However, the length independent diffusion coefficient suggests that internal rather than visc","authors_text":"Eric Vanden-Eijnden, Herbert Lannon, Jasna Brujic","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2012-07-29T15:16:07Z","title":"Force-clamp experiments reveal the free energy profile and diffusion coefficient of the collapse of proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1207.6781","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f7a1d99f2adb92b65b9b973a2c441569d2c73235f59c39a2b74b97d62830b295","target":"record","created_at":"2026-05-18T00:37:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"aec7cc5623ef1459a768eeed3df0b80cf2b6104839f696ef94bb7503d6a06d85","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2012-07-29T15:16:07Z","title_canon_sha256":"c73cb2c9893ae1efc3e97064d7292633a354b493f7b4f977764e1c7d57c7ba0e"},"schema_version":"1.0","source":{"id":"1207.6781","kind":"arxiv","version":3}},"canonical_sha256":"539cf60c17fd3f71e242f617613f56bf73f8fb97da2708e7469aef316aa31519","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"539cf60c17fd3f71e242f617613f56bf73f8fb97da2708e7469aef316aa31519","first_computed_at":"2026-05-18T00:37:02.516822Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:37:02.516822Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3e1VnXzpELLWOjjVDMEN90KVExsDGRwWwp3l17BqFYvR27ZfQdvNOvQimEpyEGqwRbJnd6656ZlWdMlp58yxDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:37:02.517408Z","signed_message":"canonical_sha256_bytes"},"source_id":"1207.6781","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f7a1d99f2adb92b65b9b973a2c441569d2c73235f59c39a2b74b97d62830b295","sha256:1ec7ae20a2cab4a44fbfaa69cbd5b28cec30b248df20a1e89c84807aada55f84"],"state_sha256":"6799fbd2b2437510ff480a22b3b1d48930c774d532b0ef5ce161e13a3ef489a2"}