{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:KUKAYZKZLKHSGKWVVKZU6IB7KK","short_pith_number":"pith:KUKAYZKZ","canonical_record":{"source":{"id":"1008.0576","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-08-03T15:31:06Z","cross_cats_sorted":[],"title_canon_sha256":"125e7a25f0b369babe1caa82ca4b060ca3d297eaf4561838636cf76f33c25564","abstract_canon_sha256":"232a66dbc1514e5b028644fc98300e98de3a2a225d581be7612bf7f8b7fac540"},"schema_version":"1.0"},"canonical_sha256":"55140c65595a8f232ad5aab34f203f52a4e3bd826400391c91fe394509e615ef","source":{"kind":"arxiv","id":"1008.0576","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1008.0576","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"arxiv_version","alias_value":"1008.0576v1","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1008.0576","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"pith_short_12","alias_value":"KUKAYZKZLKHS","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_16","alias_value":"KUKAYZKZLKHSGKWV","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_8","alias_value":"KUKAYZKZ","created_at":"2026-05-18T12:26:09Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:KUKAYZKZLKHSGKWVVKZU6IB7KK","target":"record","payload":{"canonical_record":{"source":{"id":"1008.0576","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-08-03T15:31:06Z","cross_cats_sorted":[],"title_canon_sha256":"125e7a25f0b369babe1caa82ca4b060ca3d297eaf4561838636cf76f33c25564","abstract_canon_sha256":"232a66dbc1514e5b028644fc98300e98de3a2a225d581be7612bf7f8b7fac540"},"schema_version":"1.0"},"canonical_sha256":"55140c65595a8f232ad5aab34f203f52a4e3bd826400391c91fe394509e615ef","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:54:37.827196Z","signature_b64":"FgraQug5zkM+srd/QckSU/fqUuQROG/TN4m+ZWWJj1FrlWNoJyjAqlwd4hMjSN1S1O87ptDiC+KAw4ug6EI0Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"55140c65595a8f232ad5aab34f203f52a4e3bd826400391c91fe394509e615ef","last_reissued_at":"2026-05-18T03:54:37.826608Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:54:37.826608Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1008.0576","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DtmKydVFlBemC8lJjFDC8KVqQOVm25Wz3vnC24lEIQC4U8b4VyfgdA2pwnZ9c+xkt+MiDjN2t3KuuL0FHbQPDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T13:49:10.587635Z"},"content_sha256":"441512bd89b03b4078a8d8f2f4e9fb86ca102098b9ec6ee2dc0dfac953b2a512","schema_version":"1.0","event_id":"sha256:441512bd89b03b4078a8d8f2f4e9fb86ca102098b9ec6ee2dc0dfac953b2a512"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:KUKAYZKZLKHSGKWVVKZU6IB7KK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Multiplexing Biochemical Signals","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Filipe Tostevin, Pieter Rein ten Wolde, Wiet de Ronde","submitted_at":"2010-08-03T15:31:06Z","abstract_excerpt":"In this paper we show that living cells can multiplex biochemical signals, i.e. transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them very specifically. We demonstrate how two binary input signals can be encoded in the concentration of a common signaling protein, which is then decoded such that each of the two output signals provides reliable information about one corresponding input. Under biologically relevant conditions the network can reach the maximum amount of information that can be transmitted, which is 2 bits."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1008.0576","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Qll3sJ3GvBEf69uAtAnGcUr3BzOFawD+7qXHwjmUchEVWB4+S8W0/gQW6mBLhaGDQYz+0nFVJx3w09XOFCBHAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T13:49:10.587983Z"},"content_sha256":"6969be9d31cc65c323d91cb3b9d7b1dcae615d3cd556f489daaef3d2f7336a03","schema_version":"1.0","event_id":"sha256:6969be9d31cc65c323d91cb3b9d7b1dcae615d3cd556f489daaef3d2f7336a03"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/bundle.json","state_url":"https://pith.science/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T13:49:10Z","links":{"resolver":"https://pith.science/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK","bundle":"https://pith.science/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/bundle.json","state":"https://pith.science/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KUKAYZKZLKHSGKWVVKZU6IB7KK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:KUKAYZKZLKHSGKWVVKZU6IB7KK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"232a66dbc1514e5b028644fc98300e98de3a2a225d581be7612bf7f8b7fac540","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-08-03T15:31:06Z","title_canon_sha256":"125e7a25f0b369babe1caa82ca4b060ca3d297eaf4561838636cf76f33c25564"},"schema_version":"1.0","source":{"id":"1008.0576","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1008.0576","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"arxiv_version","alias_value":"1008.0576v1","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1008.0576","created_at":"2026-05-18T03:54:37Z"},{"alias_kind":"pith_short_12","alias_value":"KUKAYZKZLKHS","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_16","alias_value":"KUKAYZKZLKHSGKWV","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_8","alias_value":"KUKAYZKZ","created_at":"2026-05-18T12:26:09Z"}],"graph_snapshots":[{"event_id":"sha256:6969be9d31cc65c323d91cb3b9d7b1dcae615d3cd556f489daaef3d2f7336a03","target":"graph","created_at":"2026-05-18T03:54:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In this paper we show that living cells can multiplex biochemical signals, i.e. transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them very specifically. We demonstrate how two binary input signals can be encoded in the concentration of a common signaling protein, which is then decoded such that each of the two output signals provides reliable information about one corresponding input. Under biologically relevant conditions the network can reach the maximum amount of information that can be transmitted, which is 2 bits.","authors_text":"Filipe Tostevin, Pieter Rein ten Wolde, Wiet de Ronde","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-08-03T15:31:06Z","title":"Multiplexing Biochemical Signals"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1008.0576","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:441512bd89b03b4078a8d8f2f4e9fb86ca102098b9ec6ee2dc0dfac953b2a512","target":"record","created_at":"2026-05-18T03:54:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"232a66dbc1514e5b028644fc98300e98de3a2a225d581be7612bf7f8b7fac540","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-08-03T15:31:06Z","title_canon_sha256":"125e7a25f0b369babe1caa82ca4b060ca3d297eaf4561838636cf76f33c25564"},"schema_version":"1.0","source":{"id":"1008.0576","kind":"arxiv","version":1}},"canonical_sha256":"55140c65595a8f232ad5aab34f203f52a4e3bd826400391c91fe394509e615ef","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"55140c65595a8f232ad5aab34f203f52a4e3bd826400391c91fe394509e615ef","first_computed_at":"2026-05-18T03:54:37.826608Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:54:37.826608Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"FgraQug5zkM+srd/QckSU/fqUuQROG/TN4m+ZWWJj1FrlWNoJyjAqlwd4hMjSN1S1O87ptDiC+KAw4ug6EI0Bw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:54:37.827196Z","signed_message":"canonical_sha256_bytes"},"source_id":"1008.0576","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:441512bd89b03b4078a8d8f2f4e9fb86ca102098b9ec6ee2dc0dfac953b2a512","sha256:6969be9d31cc65c323d91cb3b9d7b1dcae615d3cd556f489daaef3d2f7336a03"],"state_sha256":"284c15421923c2eec89b91861d43e998c03af00dfbcbeda2fa6556e67a1aceed"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iemiQ+Kb99WXFvP/ub/DSLK5jw3h6vzzKXK9Kvj3WB4xMp2HtxC8egGC3fgucbqji1vcItnMhJmuQoc2kYEWAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T13:49:10.590219Z","bundle_sha256":"0f81ca994f5d8cf88451e6300547aa6ad0610a444e84eb777c8ee72a25b26892"}}