{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:LQV5HE6BQ6X5GTMH33BJODGZME","short_pith_number":"pith:LQV5HE6B","schema_version":"1.0","canonical_sha256":"5c2bd393c187afd34d87dec2970cd96131097782c3ceaeff1239abbc6526089a","source":{"kind":"arxiv","id":"1808.00310","version":1},"attestation_state":"computed","paper":{"title":"Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.MN","authors_text":"Anne Poupon, Eric Reiter, Gwenha\\\"el J\\'egot, James A. Dias, Mohammed Akli Ayoub, Pascale Cr\\'epieux, Romain Yvinec, Sonia-Maria Poli","submitted_at":"2018-08-01T13:22:33Z","abstract_excerpt":"Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation. In this study, we attempted to pharmacologically profile these NAMs on the closely related luteinizing/chorionic gonadotropin hormone receptor (LH/CGR) with regards to its canonical Gs/cAMP pathway as well as \\beta-arrestin recruitment in HEK293 cells. Th"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1808.00310","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T13:22:33Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"94f68b5842dbda20f626657a13a584b3981aab4ad490fcd1a214a0dc7cd4c929","abstract_canon_sha256":"4897fbfcf326cc670cd47f1a71fdd4007e3009951af8b4e4bae47440c3a07710"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:09:06.499473Z","signature_b64":"EjW4QsmA1oaYWQwhMi87v7p7vithft4HUp+ogSVXnAyI/Gt/qO7zf5igr2V4lqp2qexfWMV5INR5Hz1x8kR2Bg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5c2bd393c187afd34d87dec2970cd96131097782c3ceaeff1239abbc6526089a","last_reissued_at":"2026-05-18T00:09:06.498941Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:09:06.498941Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.MN","authors_text":"Anne Poupon, Eric Reiter, Gwenha\\\"el J\\'egot, James A. Dias, Mohammed Akli Ayoub, Pascale Cr\\'epieux, Romain Yvinec, Sonia-Maria Poli","submitted_at":"2018-08-01T13:22:33Z","abstract_excerpt":"Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation. In this study, we attempted to pharmacologically profile these NAMs on the closely related luteinizing/chorionic gonadotropin hormone receptor (LH/CGR) with regards to its canonical Gs/cAMP pathway as well as \\beta-arrestin recruitment in HEK293 cells. Th"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.00310","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1808.00310","created_at":"2026-05-18T00:09:06.499016+00:00"},{"alias_kind":"arxiv_version","alias_value":"1808.00310v1","created_at":"2026-05-18T00:09:06.499016+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1808.00310","created_at":"2026-05-18T00:09:06.499016+00:00"},{"alias_kind":"pith_short_12","alias_value":"LQV5HE6BQ6X5","created_at":"2026-05-18T12:32:37.024351+00:00"},{"alias_kind":"pith_short_16","alias_value":"LQV5HE6BQ6X5GTMH","created_at":"2026-05-18T12:32:37.024351+00:00"},{"alias_kind":"pith_short_8","alias_value":"LQV5HE6B","created_at":"2026-05-18T12:32:37.024351+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME","json":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME.json","graph_json":"https://pith.science/api/pith-number/LQV5HE6BQ6X5GTMH33BJODGZME/graph.json","events_json":"https://pith.science/api/pith-number/LQV5HE6BQ6X5GTMH33BJODGZME/events.json","paper":"https://pith.science/paper/LQV5HE6B"},"agent_actions":{"view_html":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME","download_json":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME.json","view_paper":"https://pith.science/paper/LQV5HE6B","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1808.00310&json=true","fetch_graph":"https://pith.science/api/pith-number/LQV5HE6BQ6X5GTMH33BJODGZME/graph.json","fetch_events":"https://pith.science/api/pith-number/LQV5HE6BQ6X5GTMH33BJODGZME/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME/action/timestamp_anchor","attest_storage":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME/action/storage_attestation","attest_author":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME/action/author_attestation","sign_citation":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME/action/citation_signature","submit_replication":"https://pith.science/pith/LQV5HE6BQ6X5GTMH33BJODGZME/action/replication_record"}},"created_at":"2026-05-18T00:09:06.499016+00:00","updated_at":"2026-05-18T00:09:06.499016+00:00"}