{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:LSAZWCN3ZYKZ6NWV3SOZCNLMVN","short_pith_number":"pith:LSAZWCN3","canonical_record":{"source":{"id":"1202.4335","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2012-02-20T14:26:48Z","cross_cats_sorted":[],"title_canon_sha256":"12fab425844a21988a94f97e02cf905d8495f38856073857400babac63f6e634","abstract_canon_sha256":"9911f5d0565d433ac765e46869fbf0fd39d52bf0dd8071dec09988ac030b304a"},"schema_version":"1.0"},"canonical_sha256":"5c819b09bbce159f36d5dc9d91356cab67fb41f2532ea912df16c74a9f083d22","source":{"kind":"arxiv","id":"1202.4335","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.4335","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"arxiv_version","alias_value":"1202.4335v1","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.4335","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"pith_short_12","alias_value":"LSAZWCN3ZYKZ","created_at":"2026-05-18T12:27:14Z"},{"alias_kind":"pith_short_16","alias_value":"LSAZWCN3ZYKZ6NWV","created_at":"2026-05-18T12:27:14Z"},{"alias_kind":"pith_short_8","alias_value":"LSAZWCN3","created_at":"2026-05-18T12:27:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:LSAZWCN3ZYKZ6NWV3SOZCNLMVN","target":"record","payload":{"canonical_record":{"source":{"id":"1202.4335","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2012-02-20T14:26:48Z","cross_cats_sorted":[],"title_canon_sha256":"12fab425844a21988a94f97e02cf905d8495f38856073857400babac63f6e634","abstract_canon_sha256":"9911f5d0565d433ac765e46869fbf0fd39d52bf0dd8071dec09988ac030b304a"},"schema_version":"1.0"},"canonical_sha256":"5c819b09bbce159f36d5dc9d91356cab67fb41f2532ea912df16c74a9f083d22","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:58:23.533952Z","signature_b64":"aD/X/jgFFWWLZ/MBJNYTtRagiRMspb+39CFDHDzRZWYS1qsC42k4j2/3kblt31MXQrZS5nWcX3qyXWg6Aqp9DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5c819b09bbce159f36d5dc9d91356cab67fb41f2532ea912df16c74a9f083d22","last_reissued_at":"2026-05-18T01:58:23.533500Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:58:23.533500Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1202.4335","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:58:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SkeETaouLFF6Os0Ziw1vQnzkDfvKeoc1c/cHCzL7y3yNmrUuEktmgltK3Z0QToaB6dyR3ttEmzKVvT2j6W53Aw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T08:46:28.244293Z"},"content_sha256":"2bfaf4ca9b2781ec121cea22b8660056aa84e6a2c8374995da06fcfa389ff92f","schema_version":"1.0","event_id":"sha256:2bfaf4ca9b2781ec121cea22b8660056aa84e6a2c8374995da06fcfa389ff92f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:LSAZWCN3ZYKZ6NWV3SOZCNLMVN","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Modeling Regulation of Zinc Uptake via ZIP Transporters in Yeast and Plant Roots","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Andr\\'es Chavarr\\'ia-Krauser, Juliane Claus","submitted_at":"2012-02-20T14:26:48Z","abstract_excerpt":"In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into the underlying mechanisms, starting from a general model based on ordinary differential equations and adapting it to the specific cases of yeast and plant root cells. In yeast, zinc is transported by the transporters ZRT1 and ZRT2, which are both regulated by the zinc-responsive transcription factor "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.4335","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:58:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7RYVe84yR+4e5to2ctnCMkI96b8xAVempurECvPChVlkoeXOWwsoal6i8p34SIA2cln9q1XXZl3Smnz7tjJ7DA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T08:46:28.244647Z"},"content_sha256":"3275d25c385db8ea675f0e7976dfcaba398cf61a8b234b3db3eece4c20ce31c4","schema_version":"1.0","event_id":"sha256:3275d25c385db8ea675f0e7976dfcaba398cf61a8b234b3db3eece4c20ce31c4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/bundle.json","state_url":"https://pith.science/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T08:46:28Z","links":{"resolver":"https://pith.science/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN","bundle":"https://pith.science/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/bundle.json","state":"https://pith.science/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/state.json","well_known_bundle":"https://pith.science/.well-known/pith/LSAZWCN3ZYKZ6NWV3SOZCNLMVN/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:LSAZWCN3ZYKZ6NWV3SOZCNLMVN","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9911f5d0565d433ac765e46869fbf0fd39d52bf0dd8071dec09988ac030b304a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2012-02-20T14:26:48Z","title_canon_sha256":"12fab425844a21988a94f97e02cf905d8495f38856073857400babac63f6e634"},"schema_version":"1.0","source":{"id":"1202.4335","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.4335","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"arxiv_version","alias_value":"1202.4335v1","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.4335","created_at":"2026-05-18T01:58:23Z"},{"alias_kind":"pith_short_12","alias_value":"LSAZWCN3ZYKZ","created_at":"2026-05-18T12:27:14Z"},{"alias_kind":"pith_short_16","alias_value":"LSAZWCN3ZYKZ6NWV","created_at":"2026-05-18T12:27:14Z"},{"alias_kind":"pith_short_8","alias_value":"LSAZWCN3","created_at":"2026-05-18T12:27:14Z"}],"graph_snapshots":[{"event_id":"sha256:3275d25c385db8ea675f0e7976dfcaba398cf61a8b234b3db3eece4c20ce31c4","target":"graph","created_at":"2026-05-18T01:58:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into the underlying mechanisms, starting from a general model based on ordinary differential equations and adapting it to the specific cases of yeast and plant root cells. In yeast, zinc is transported by the transporters ZRT1 and ZRT2, which are both regulated by the zinc-responsive transcription factor ","authors_text":"Andr\\'es Chavarr\\'ia-Krauser, Juliane Claus","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2012-02-20T14:26:48Z","title":"Modeling Regulation of Zinc Uptake via ZIP Transporters in Yeast and Plant Roots"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.4335","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2bfaf4ca9b2781ec121cea22b8660056aa84e6a2c8374995da06fcfa389ff92f","target":"record","created_at":"2026-05-18T01:58:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9911f5d0565d433ac765e46869fbf0fd39d52bf0dd8071dec09988ac030b304a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2012-02-20T14:26:48Z","title_canon_sha256":"12fab425844a21988a94f97e02cf905d8495f38856073857400babac63f6e634"},"schema_version":"1.0","source":{"id":"1202.4335","kind":"arxiv","version":1}},"canonical_sha256":"5c819b09bbce159f36d5dc9d91356cab67fb41f2532ea912df16c74a9f083d22","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5c819b09bbce159f36d5dc9d91356cab67fb41f2532ea912df16c74a9f083d22","first_computed_at":"2026-05-18T01:58:23.533500Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:58:23.533500Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aD/X/jgFFWWLZ/MBJNYTtRagiRMspb+39CFDHDzRZWYS1qsC42k4j2/3kblt31MXQrZS5nWcX3qyXWg6Aqp9DQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:58:23.533952Z","signed_message":"canonical_sha256_bytes"},"source_id":"1202.4335","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2bfaf4ca9b2781ec121cea22b8660056aa84e6a2c8374995da06fcfa389ff92f","sha256:3275d25c385db8ea675f0e7976dfcaba398cf61a8b234b3db3eece4c20ce31c4"],"state_sha256":"9e8050b6944b21c62e345f8711fa589ef788d3966bdb6245bfe64832140d3d86"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PHPtpVHRYwt7BO8e5vbjF7oLhNl77ltGJX6iwMzu9DlExHfYoXN0LE5NDeb/XOaYxCihHyYAsNtm+JKU84CtBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T08:46:28.246660Z","bundle_sha256":"9badfd7ae83d45b0c9abba034eca1c57f0a0829dc13bc2294cb0fef86d40188d"}}