{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:MJIFGLXHJ4JM54ZHYMA6FXYOVV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1520dfc72694ff757cdcf5c3ae1c97efe7844eaf702c63e83edffc9b0d698b83","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-03-31T15:39:13Z","title_canon_sha256":"97291b1d27b79d0655fc157ddb8b9019723d38faaf74970d1a30c23f96975f76"},"schema_version":"1.0","source":{"id":"1703.10948","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1703.10948","created_at":"2026-05-18T00:33:06Z"},{"alias_kind":"arxiv_version","alias_value":"1703.10948v2","created_at":"2026-05-18T00:33:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1703.10948","created_at":"2026-05-18T00:33:06Z"},{"alias_kind":"pith_short_12","alias_value":"MJIFGLXHJ4JM","created_at":"2026-05-18T12:31:31Z"},{"alias_kind":"pith_short_16","alias_value":"MJIFGLXHJ4JM54ZH","created_at":"2026-05-18T12:31:31Z"},{"alias_kind":"pith_short_8","alias_value":"MJIFGLXH","created_at":"2026-05-18T12:31:31Z"}],"graph_snapshots":[{"event_id":"sha256:8ae315be8e1ba3646857d5f880f41166e8d51607a8f4826d4f7ab9b2e99920d6","target":"graph","created_at":"2026-05-18T00:33:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Recent experiments and simulations have demonstrated that proteins can fold on the ribosome. However, the extent and generality of fitness effects resulting from co-translational folding remain open questions. Here we report a genome-wide analysis that uncovers evidence of evolutionary selection for co-translational folding. We describe a robust statistical approach to identify loci within genes that are both significantly enriched in slowly translated codons and evolutionarily conserved. Surprisingly, we find that domain boundaries can explain only a small fraction of these conserved loci. In","authors_text":"Eugene I Shakhnovich, William M Jacobs","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-03-31T15:39:13Z","title":"Evidence of evolutionary selection for co-translational folding"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1703.10948","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f7456c6bf1742bd3e9ef2b539455d55064596dea27e4d55e83e83820076221df","target":"record","created_at":"2026-05-18T00:33:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1520dfc72694ff757cdcf5c3ae1c97efe7844eaf702c63e83edffc9b0d698b83","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-03-31T15:39:13Z","title_canon_sha256":"97291b1d27b79d0655fc157ddb8b9019723d38faaf74970d1a30c23f96975f76"},"schema_version":"1.0","source":{"id":"1703.10948","kind":"arxiv","version":2}},"canonical_sha256":"6250532ee74f12cef327c301e2df0ead4601e7fb9413ab3311abc790f63eecb3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6250532ee74f12cef327c301e2df0ead4601e7fb9413ab3311abc790f63eecb3","first_computed_at":"2026-05-18T00:33:06.706190Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:33:06.706190Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"fn4ZMtZS/IY1UB2wrdGIcrquGdfLcBZPoyO5xy6cOiITB7YN+Vfn1YHFltc5oiud4gAH1WmdVFqvJu68SdjNAA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:33:06.706752Z","signed_message":"canonical_sha256_bytes"},"source_id":"1703.10948","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f7456c6bf1742bd3e9ef2b539455d55064596dea27e4d55e83e83820076221df","sha256:8ae315be8e1ba3646857d5f880f41166e8d51607a8f4826d4f7ab9b2e99920d6"],"state_sha256":"e5a16bb344d6b8eaecd2cd774ad1cfcb88179aac4f939c176c0b6e463bb62cdc"}