{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:NAICUIUGZ22TUCJXUPYCHARPFS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"33a751a0d2a89ec80d0b202d9e3f9f8d7a1ce7ee3b0fcbcae9455240a9cd9712","cross_cats_sorted":["cs.AI","cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-05-08T15:29:36Z","title_canon_sha256":"4dd9de0e9c9e0a6b907d650c66cdef19d70a7b1d109836abe5681cbd1a6940ca"},"schema_version":"1.0","source":{"id":"2605.21502","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.21502","created_at":"2026-05-22T00:02:27Z"},{"alias_kind":"arxiv_version","alias_value":"2605.21502v1","created_at":"2026-05-22T00:02:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.21502","created_at":"2026-05-22T00:02:27Z"},{"alias_kind":"pith_short_12","alias_value":"NAICUIUGZ22T","created_at":"2026-05-22T00:02:27Z"},{"alias_kind":"pith_short_16","alias_value":"NAICUIUGZ22TUCJX","created_at":"2026-05-22T00:02:27Z"},{"alias_kind":"pith_short_8","alias_value":"NAICUIUG","created_at":"2026-05-22T00:02:27Z"}],"graph_snapshots":[{"event_id":"sha256:55dd7b80379cda65639641e2750a7cb9cf5ca954b954b21e2bb59e4d3c1df770","target":"graph","created_at":"2026-05-22T00:02:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2605.21502/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Graph neural networks (GNNs) are increasingly used to model biological systems, yet the reliability of post-hoc explanation methods for recovering meaningful molecular mechanisms remains unclear. Here, we systematically evaluate four widely used approaches: Saliency Attribution (SA), Integrated Gradients (IG), GNNExplainer, and Layer-wise Relevance Propagation (LRP) for identifying disease-relevant structure in breast cancer RNA-seq data projected onto a protein-protein interaction network. Using synthetic benchmarks with known ground-truth motifs, we show that explanation methods recover dist","authors_text":"Dennis Veselkov, Ivan Laponogov, Kirill Veselkov, Kyle Higgins","cross_cats":["cs.AI","cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-05-08T15:29:36Z","title":"Graph neural network explanations reveal a topological signature of disease-associated hubs in biological networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.21502","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b371517e80aae053b5bdc3edc2226a6e5bb9a07ff56acb3266620cd47843e2e7","target":"record","created_at":"2026-05-22T00:02:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"33a751a0d2a89ec80d0b202d9e3f9f8d7a1ce7ee3b0fcbcae9455240a9cd9712","cross_cats_sorted":["cs.AI","cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-05-08T15:29:36Z","title_canon_sha256":"4dd9de0e9c9e0a6b907d650c66cdef19d70a7b1d109836abe5681cbd1a6940ca"},"schema_version":"1.0","source":{"id":"2605.21502","kind":"arxiv","version":1}},"canonical_sha256":"68102a2286ceb53a0937a3f023822f2c8f6ca9338c4ea5f30ce908b68174b931","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"68102a2286ceb53a0937a3f023822f2c8f6ca9338c4ea5f30ce908b68174b931","first_computed_at":"2026-05-22T00:02:27.115184Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-22T00:02:27.115184Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Hi1ZjLVSXQdD88klR0WPObzNJ6oLXxpzUC97s303WklcH8bMNskAKPfHZpxuDxr3YKcJ62jfyVXFD2zf9kwDBw==","signature_status":"signed_v1","signed_at":"2026-05-22T00:02:27.115674Z","signed_message":"canonical_sha256_bytes"},"source_id":"2605.21502","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b371517e80aae053b5bdc3edc2226a6e5bb9a07ff56acb3266620cd47843e2e7","sha256:55dd7b80379cda65639641e2750a7cb9cf5ca954b954b21e2bb59e4d3c1df770"],"state_sha256":"6349344dfb545fb0e95563d9fb33db74a438a0d625256b1f8903a5f56cb7c6b2"}