{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:NIINNAEHBIU6ESHHP2SCGLPYCT","short_pith_number":"pith:NIINNAEH","canonical_record":{"source":{"id":"1411.1399","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-11-05T03:25:02Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"a5285ecd339f93fcdeff89ae15ae6650309b8b2337a4c5ba8b7ff0fb90474fd5","abstract_canon_sha256":"3315a2ce8b0a9275187c5759167db1aa93b9d3ed5b6dad0bb200a90deba43992"},"schema_version":"1.0"},"canonical_sha256":"6a10d680870a29e248e77ea4232df814c5d743ac84b9d5dea1325dda186dc4c1","source":{"kind":"arxiv","id":"1411.1399","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1411.1399","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"arxiv_version","alias_value":"1411.1399v1","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1411.1399","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"pith_short_12","alias_value":"NIINNAEHBIU6","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_16","alias_value":"NIINNAEHBIU6ESHH","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_8","alias_value":"NIINNAEH","created_at":"2026-05-18T12:28:41Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:NIINNAEHBIU6ESHHP2SCGLPYCT","target":"record","payload":{"canonical_record":{"source":{"id":"1411.1399","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-11-05T03:25:02Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"a5285ecd339f93fcdeff89ae15ae6650309b8b2337a4c5ba8b7ff0fb90474fd5","abstract_canon_sha256":"3315a2ce8b0a9275187c5759167db1aa93b9d3ed5b6dad0bb200a90deba43992"},"schema_version":"1.0"},"canonical_sha256":"6a10d680870a29e248e77ea4232df814c5d743ac84b9d5dea1325dda186dc4c1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:38:28.076393Z","signature_b64":"tAetb+ymtk7VW9J+WvC5VaKSNjzHykQsN3w7KyfsHT+GeTr7ALkzgrL2s5Y5q31AfMXuZ+AojjIY7TVLIrtsAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6a10d680870a29e248e77ea4232df814c5d743ac84b9d5dea1325dda186dc4c1","last_reissued_at":"2026-05-18T02:38:28.075706Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:38:28.075706Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1411.1399","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:38:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TtnHF+f5fg4cCFczOM1eGobLZe+bvOF7bfMVIBG3aGjv8h/qkK4lGAhAuEBZjImGaDNfmscH6p8CuPi+IGfNCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T13:46:26.014788Z"},"content_sha256":"8681c9e4a7b73848c4eb9313bc4fb5797738d2bf0cdc33fe79fb60d319299183","schema_version":"1.0","event_id":"sha256:8681c9e4a7b73848c4eb9313bc4fb5797738d2bf0cdc33fe79fb60d319299183"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:NIINNAEHBIU6ESHHP2SCGLPYCT","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Replicator Dynamics of of Cancer Stem Cell; Selection in the Presence of Differentiation and Plasticity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.CB","authors_text":"Kamran Kaveh, Mohammad Kohandel, Siv Sivaloganathan","submitted_at":"2014-11-05T03:25:02Z","abstract_excerpt":"Stem cells have the potential to produce lineages of non-stem cell populations (differentiated cells) via a ubiquitous hierarchal division scheme. Differentiation of a stem cell into (partially) differentiated cells can happen either symmetrically or asymmetrically. The selection dynamics of a mutant cancer stem cell should be investigated in the light of a stem cell proliferation hierarchy and presence of a non-stem cell population. By constructing a three-compartment Moran-type model composed of normal stem cells, mutant (cancer) stem cells and differentiated cells, we derive the replicator "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1411.1399","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:38:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/9PguxdpsbSPrV3vREAGhZzOi2brrBFsGYYdK2zYaDaUAMXLez3sFHNwyXqDiprKR7Q6yrHU3RL2qMSWPGobCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T13:46:26.015138Z"},"content_sha256":"aed9fdd1b966d8984111d05812dc39311556bf898e1800b17942637b6a325afb","schema_version":"1.0","event_id":"sha256:aed9fdd1b966d8984111d05812dc39311556bf898e1800b17942637b6a325afb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/bundle.json","state_url":"https://pith.science/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-01T13:46:26Z","links":{"resolver":"https://pith.science/pith/NIINNAEHBIU6ESHHP2SCGLPYCT","bundle":"https://pith.science/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/bundle.json","state":"https://pith.science/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NIINNAEHBIU6ESHHP2SCGLPYCT/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:NIINNAEHBIU6ESHHP2SCGLPYCT","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3315a2ce8b0a9275187c5759167db1aa93b9d3ed5b6dad0bb200a90deba43992","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-11-05T03:25:02Z","title_canon_sha256":"a5285ecd339f93fcdeff89ae15ae6650309b8b2337a4c5ba8b7ff0fb90474fd5"},"schema_version":"1.0","source":{"id":"1411.1399","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1411.1399","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"arxiv_version","alias_value":"1411.1399v1","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1411.1399","created_at":"2026-05-18T02:38:28Z"},{"alias_kind":"pith_short_12","alias_value":"NIINNAEHBIU6","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_16","alias_value":"NIINNAEHBIU6ESHH","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_8","alias_value":"NIINNAEH","created_at":"2026-05-18T12:28:41Z"}],"graph_snapshots":[{"event_id":"sha256:aed9fdd1b966d8984111d05812dc39311556bf898e1800b17942637b6a325afb","target":"graph","created_at":"2026-05-18T02:38:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Stem cells have the potential to produce lineages of non-stem cell populations (differentiated cells) via a ubiquitous hierarchal division scheme. Differentiation of a stem cell into (partially) differentiated cells can happen either symmetrically or asymmetrically. The selection dynamics of a mutant cancer stem cell should be investigated in the light of a stem cell proliferation hierarchy and presence of a non-stem cell population. By constructing a three-compartment Moran-type model composed of normal stem cells, mutant (cancer) stem cells and differentiated cells, we derive the replicator ","authors_text":"Kamran Kaveh, Mohammad Kohandel, Siv Sivaloganathan","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-11-05T03:25:02Z","title":"Replicator Dynamics of of Cancer Stem Cell; Selection in the Presence of Differentiation and Plasticity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1411.1399","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8681c9e4a7b73848c4eb9313bc4fb5797738d2bf0cdc33fe79fb60d319299183","target":"record","created_at":"2026-05-18T02:38:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3315a2ce8b0a9275187c5759167db1aa93b9d3ed5b6dad0bb200a90deba43992","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-11-05T03:25:02Z","title_canon_sha256":"a5285ecd339f93fcdeff89ae15ae6650309b8b2337a4c5ba8b7ff0fb90474fd5"},"schema_version":"1.0","source":{"id":"1411.1399","kind":"arxiv","version":1}},"canonical_sha256":"6a10d680870a29e248e77ea4232df814c5d743ac84b9d5dea1325dda186dc4c1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6a10d680870a29e248e77ea4232df814c5d743ac84b9d5dea1325dda186dc4c1","first_computed_at":"2026-05-18T02:38:28.075706Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:38:28.075706Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"tAetb+ymtk7VW9J+WvC5VaKSNjzHykQsN3w7KyfsHT+GeTr7ALkzgrL2s5Y5q31AfMXuZ+AojjIY7TVLIrtsAg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:38:28.076393Z","signed_message":"canonical_sha256_bytes"},"source_id":"1411.1399","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8681c9e4a7b73848c4eb9313bc4fb5797738d2bf0cdc33fe79fb60d319299183","sha256:aed9fdd1b966d8984111d05812dc39311556bf898e1800b17942637b6a325afb"],"state_sha256":"5f800323e4aa1d628ca721fe14a65770e4a6fecf8a90fd3db0cad07b41fec5b5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"V+FSo97m7aOt09+4W2uOeQv17x7e3c3fNEyLjnhzgyMMITI5Hld0utnsRP9WVc/AtoToEC0+vdgwOs27stBcCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-01T13:46:26.017307Z","bundle_sha256":"f730e979b36cc2e874a7c315e87d615001d5f80999d323e93394a4401fdc9525"}}