{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:NT4ATM3AUDDETQPLR2RCIQ2WU2","short_pith_number":"pith:NT4ATM3A","canonical_record":{"source":{"id":"1005.1088","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-05-06T21:21:31Z","cross_cats_sorted":[],"title_canon_sha256":"042cb2dab61ecd205ed61b6fe75aed8418b9b955ef8dc3ce88d55cd906a199f7","abstract_canon_sha256":"b42ce5df67285b908b0b6efb81007a71f905c4bbb58e021d3abba4e6a5bb1653"},"schema_version":"1.0"},"canonical_sha256":"6cf809b360a0c649c1eb8ea2244356a681370cfb3b6f90cb43eebe6ff11a9c57","source":{"kind":"arxiv","id":"1005.1088","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1005.1088","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"arxiv_version","alias_value":"1005.1088v1","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1005.1088","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"pith_short_12","alias_value":"NT4ATM3AUDDE","created_at":"2026-05-18T12:26:10Z"},{"alias_kind":"pith_short_16","alias_value":"NT4ATM3AUDDETQPL","created_at":"2026-05-18T12:26:10Z"},{"alias_kind":"pith_short_8","alias_value":"NT4ATM3A","created_at":"2026-05-18T12:26:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:NT4ATM3AUDDETQPLR2RCIQ2WU2","target":"record","payload":{"canonical_record":{"source":{"id":"1005.1088","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-05-06T21:21:31Z","cross_cats_sorted":[],"title_canon_sha256":"042cb2dab61ecd205ed61b6fe75aed8418b9b955ef8dc3ce88d55cd906a199f7","abstract_canon_sha256":"b42ce5df67285b908b0b6efb81007a71f905c4bbb58e021d3abba4e6a5bb1653"},"schema_version":"1.0"},"canonical_sha256":"6cf809b360a0c649c1eb8ea2244356a681370cfb3b6f90cb43eebe6ff11a9c57","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:07:41.917398Z","signature_b64":"Flr4cI42yIIKWj3rehXvxrDYifpD8wZY9gOpE8Rg5u20WOyPiQI3MRF6AqUWbcebHx7a4LXY/hbT9D3vMGrPBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6cf809b360a0c649c1eb8ea2244356a681370cfb3b6f90cb43eebe6ff11a9c57","last_reissued_at":"2026-05-18T02:07:41.916588Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:07:41.916588Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1005.1088","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:07:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kDBw1ZZEWTyIJcR6ZZgHkHVpbewUrVYasciKYY47suRj5Eq5J9RzSORDgZs3MZYiF+tbWZYpt6E64wp0SOsFAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T07:37:31.613862Z"},"content_sha256":"1b496def680a25a45f0f22d91450c4f72f3b4354026f35e008fcda509ed6aa73","schema_version":"1.0","event_id":"sha256:1b496def680a25a45f0f22d91450c4f72f3b4354026f35e008fcda509ed6aa73"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:NT4ATM3AUDDETQPLR2RCIQ2WU2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Byron Goldstein, Daniel Coombs, Michael L. Dustin, Ryan N. Gutenkunst, Toby Star","submitted_at":"2010-05-06T21:21:31Z","abstract_excerpt":"A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells. Thus it is important to understand adhesion of cells by antibodies and similar molecules. We present an equilibrium model of such adhesion, incorporating heterogeneity in target cell epitope density and epitope immobility. We compare with experiments on the adhesion of Jurkat T cells to bilayers "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1005.1088","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:07:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4syxyk8Qd9lIVqJGy/KUhKOk6t7M6D+Ma7uvnhlN4m41k3qo6rINOpdQTW+q+emJLeM2QsZPJCxKUxObTha3AQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T07:37:31.614205Z"},"content_sha256":"df30b41965310118b4a6cb9ae3197f53984137560a313acfd6e956f52ce67fc0","schema_version":"1.0","event_id":"sha256:df30b41965310118b4a6cb9ae3197f53984137560a313acfd6e956f52ce67fc0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/bundle.json","state_url":"https://pith.science/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-21T07:37:31Z","links":{"resolver":"https://pith.science/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2","bundle":"https://pith.science/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/bundle.json","state":"https://pith.science/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NT4ATM3AUDDETQPLR2RCIQ2WU2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:NT4ATM3AUDDETQPLR2RCIQ2WU2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b42ce5df67285b908b0b6efb81007a71f905c4bbb58e021d3abba4e6a5bb1653","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-05-06T21:21:31Z","title_canon_sha256":"042cb2dab61ecd205ed61b6fe75aed8418b9b955ef8dc3ce88d55cd906a199f7"},"schema_version":"1.0","source":{"id":"1005.1088","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1005.1088","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"arxiv_version","alias_value":"1005.1088v1","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1005.1088","created_at":"2026-05-18T02:07:41Z"},{"alias_kind":"pith_short_12","alias_value":"NT4ATM3AUDDE","created_at":"2026-05-18T12:26:10Z"},{"alias_kind":"pith_short_16","alias_value":"NT4ATM3AUDDETQPL","created_at":"2026-05-18T12:26:10Z"},{"alias_kind":"pith_short_8","alias_value":"NT4ATM3A","created_at":"2026-05-18T12:26:10Z"}],"graph_snapshots":[{"event_id":"sha256:df30b41965310118b4a6cb9ae3197f53984137560a313acfd6e956f52ce67fc0","target":"graph","created_at":"2026-05-18T02:07:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells. Thus it is important to understand adhesion of cells by antibodies and similar molecules. We present an equilibrium model of such adhesion, incorporating heterogeneity in target cell epitope density and epitope immobility. We compare with experiments on the adhesion of Jurkat T cells to bilayers ","authors_text":"Byron Goldstein, Daniel Coombs, Michael L. Dustin, Ryan N. Gutenkunst, Toby Star","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-05-06T21:21:31Z","title":"A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1005.1088","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1b496def680a25a45f0f22d91450c4f72f3b4354026f35e008fcda509ed6aa73","target":"record","created_at":"2026-05-18T02:07:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b42ce5df67285b908b0b6efb81007a71f905c4bbb58e021d3abba4e6a5bb1653","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2010-05-06T21:21:31Z","title_canon_sha256":"042cb2dab61ecd205ed61b6fe75aed8418b9b955ef8dc3ce88d55cd906a199f7"},"schema_version":"1.0","source":{"id":"1005.1088","kind":"arxiv","version":1}},"canonical_sha256":"6cf809b360a0c649c1eb8ea2244356a681370cfb3b6f90cb43eebe6ff11a9c57","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6cf809b360a0c649c1eb8ea2244356a681370cfb3b6f90cb43eebe6ff11a9c57","first_computed_at":"2026-05-18T02:07:41.916588Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:07:41.916588Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Flr4cI42yIIKWj3rehXvxrDYifpD8wZY9gOpE8Rg5u20WOyPiQI3MRF6AqUWbcebHx7a4LXY/hbT9D3vMGrPBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:07:41.917398Z","signed_message":"canonical_sha256_bytes"},"source_id":"1005.1088","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1b496def680a25a45f0f22d91450c4f72f3b4354026f35e008fcda509ed6aa73","sha256:df30b41965310118b4a6cb9ae3197f53984137560a313acfd6e956f52ce67fc0"],"state_sha256":"78e7d7b894e7aff3cbb45cfab9267e9a173c3ae56e587fdfb9e3aa3eb9baf720"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JfPmdrseTPHAOkIR2/hNudyD3a/LQ+nzKR8Hea6ItvALyEqFD/Og7aYQYUVeitJ7d9szBngpfHOgkWiBelhGBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-21T07:37:31.616129Z","bundle_sha256":"c6b2cb185fdee3580101e2c859e67de1d440eaeb234e5684ba4889eeaf691f8e"}}