{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:ODALM4VTPEJB4NYXUR72ZSHKNI","short_pith_number":"pith:ODALM4VT","canonical_record":{"source":{"id":"1402.1835","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-02-08T08:56:46Z","cross_cats_sorted":[],"title_canon_sha256":"903ba867d44a1027e051efa978e9fec28da7979541d011caeabd20ed078b9d31","abstract_canon_sha256":"429b7c6e74ea2839e1075e08f877165cb50ccde4d8a02c905bf1a5f9d561894f"},"schema_version":"1.0"},"canonical_sha256":"70c0b672b379121e3717a47facc8ea6a346e975db75f77837bd91762c6576b1e","source":{"kind":"arxiv","id":"1402.1835","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1402.1835","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"arxiv_version","alias_value":"1402.1835v1","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1402.1835","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"pith_short_12","alias_value":"ODALM4VTPEJB","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_16","alias_value":"ODALM4VTPEJB4NYX","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_8","alias_value":"ODALM4VT","created_at":"2026-05-18T12:28:41Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:ODALM4VTPEJB4NYXUR72ZSHKNI","target":"record","payload":{"canonical_record":{"source":{"id":"1402.1835","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-02-08T08:56:46Z","cross_cats_sorted":[],"title_canon_sha256":"903ba867d44a1027e051efa978e9fec28da7979541d011caeabd20ed078b9d31","abstract_canon_sha256":"429b7c6e74ea2839e1075e08f877165cb50ccde4d8a02c905bf1a5f9d561894f"},"schema_version":"1.0"},"canonical_sha256":"70c0b672b379121e3717a47facc8ea6a346e975db75f77837bd91762c6576b1e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:59:33.394859Z","signature_b64":"kbjQ8hNmSCKcAqhNIWMHdlE6QjW0pQCoav5PLxmWElbsvb6A18Us3tqHCzyZCbd1sH3m/BzR+87r02bpog7BAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"70c0b672b379121e3717a47facc8ea6a346e975db75f77837bd91762c6576b1e","last_reissued_at":"2026-05-18T02:59:33.394134Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:59:33.394134Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1402.1835","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:59:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6o5SSVTxtHz0/aPY4+gLkzqrGs7TDipbbYKXhW9VOEHLfUcvTH38qlIPkjmj9hp8fcRBX9/baIfz5pRBWUbbAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T11:57:39.364428Z"},"content_sha256":"390d2f64ae8e1a95997c17a453c6e8ec5a27dfbbbf0dca11a6c415e6fecbd70a","schema_version":"1.0","event_id":"sha256:390d2f64ae8e1a95997c17a453c6e8ec5a27dfbbbf0dca11a6c415e6fecbd70a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:ODALM4VTPEJB4NYXUR72ZSHKNI","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A model-free estimation for the covariate-adjusted Youden index and its associated cut-point","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Junhui Wang, Tu Xu, Yixin Fang","submitted_at":"2014-02-08T08:56:46Z","abstract_excerpt":"In medical research, continuous markers are widely employed in diagnostic tests to distinguish diseased and non-diseased subjects. The accuracy of such diagnostic tests is commonly assessed using the receiver operating characteristic (ROC) curve. To summarize an ROC curve and determine its optimal cut-point, the Youden index is popularly used. In literature, estimation of the Youden index has been widely studied via various statistical modeling strategies on the conditional density. This paper proposes a new model-free estimation method, which directly estimates the covariate-adjusted cut-poin"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1402.1835","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:59:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"bZw9HGuJ1EdkR6iYfohvbF8kIFADbJvYtT2em3b/gKREVO+ZQeMKkpQLZjBwPuvqT5fo0Em+xBsirdOSzBeJAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T11:57:39.364774Z"},"content_sha256":"0aca1a704bd3b610b00dca9696abbcb3373b3b2ab3d129e01c25804eee8f953d","schema_version":"1.0","event_id":"sha256:0aca1a704bd3b610b00dca9696abbcb3373b3b2ab3d129e01c25804eee8f953d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/bundle.json","state_url":"https://pith.science/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-03T11:57:39Z","links":{"resolver":"https://pith.science/pith/ODALM4VTPEJB4NYXUR72ZSHKNI","bundle":"https://pith.science/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/bundle.json","state":"https://pith.science/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ODALM4VTPEJB4NYXUR72ZSHKNI/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:ODALM4VTPEJB4NYXUR72ZSHKNI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"429b7c6e74ea2839e1075e08f877165cb50ccde4d8a02c905bf1a5f9d561894f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-02-08T08:56:46Z","title_canon_sha256":"903ba867d44a1027e051efa978e9fec28da7979541d011caeabd20ed078b9d31"},"schema_version":"1.0","source":{"id":"1402.1835","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1402.1835","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"arxiv_version","alias_value":"1402.1835v1","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1402.1835","created_at":"2026-05-18T02:59:33Z"},{"alias_kind":"pith_short_12","alias_value":"ODALM4VTPEJB","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_16","alias_value":"ODALM4VTPEJB4NYX","created_at":"2026-05-18T12:28:41Z"},{"alias_kind":"pith_short_8","alias_value":"ODALM4VT","created_at":"2026-05-18T12:28:41Z"}],"graph_snapshots":[{"event_id":"sha256:0aca1a704bd3b610b00dca9696abbcb3373b3b2ab3d129e01c25804eee8f953d","target":"graph","created_at":"2026-05-18T02:59:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In medical research, continuous markers are widely employed in diagnostic tests to distinguish diseased and non-diseased subjects. The accuracy of such diagnostic tests is commonly assessed using the receiver operating characteristic (ROC) curve. To summarize an ROC curve and determine its optimal cut-point, the Youden index is popularly used. In literature, estimation of the Youden index has been widely studied via various statistical modeling strategies on the conditional density. This paper proposes a new model-free estimation method, which directly estimates the covariate-adjusted cut-poin","authors_text":"Junhui Wang, Tu Xu, Yixin Fang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-02-08T08:56:46Z","title":"A model-free estimation for the covariate-adjusted Youden index and its associated cut-point"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1402.1835","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:390d2f64ae8e1a95997c17a453c6e8ec5a27dfbbbf0dca11a6c415e6fecbd70a","target":"record","created_at":"2026-05-18T02:59:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"429b7c6e74ea2839e1075e08f877165cb50ccde4d8a02c905bf1a5f9d561894f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-02-08T08:56:46Z","title_canon_sha256":"903ba867d44a1027e051efa978e9fec28da7979541d011caeabd20ed078b9d31"},"schema_version":"1.0","source":{"id":"1402.1835","kind":"arxiv","version":1}},"canonical_sha256":"70c0b672b379121e3717a47facc8ea6a346e975db75f77837bd91762c6576b1e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"70c0b672b379121e3717a47facc8ea6a346e975db75f77837bd91762c6576b1e","first_computed_at":"2026-05-18T02:59:33.394134Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:59:33.394134Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"kbjQ8hNmSCKcAqhNIWMHdlE6QjW0pQCoav5PLxmWElbsvb6A18Us3tqHCzyZCbd1sH3m/BzR+87r02bpog7BAA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:59:33.394859Z","signed_message":"canonical_sha256_bytes"},"source_id":"1402.1835","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:390d2f64ae8e1a95997c17a453c6e8ec5a27dfbbbf0dca11a6c415e6fecbd70a","sha256:0aca1a704bd3b610b00dca9696abbcb3373b3b2ab3d129e01c25804eee8f953d"],"state_sha256":"644161f415ffa6a71c4b837ed3770e51c23464ddb3b096d9addedf9e6992ec94"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/uTnggGSQl80p4EuiTbizOaE0DEsrcNZWdYSTbHFfPOEBrvB9QwMLvp/aizzXYjAaCVa4e50su5uWDrPDcRdCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-03T11:57:39.366588Z","bundle_sha256":"935d6973731e57ad15e5f4acc4f10583db67ba4d1361045fff2c012f78a211e3"}}