{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2005:ORN7IKSHVZH4C7NCR4VSVBH55S","short_pith_number":"pith:ORN7IKSH","canonical_record":{"source":{"id":"q-bio/0509018","kind":"arxiv","version":2},"metadata":{"license":"","primary_cat":"q-bio.BM","submitted_at":"2005-09-15T00:17:46Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"6070492261b7ee7982184dad91fe5fee1633aa76939e57f4cab19da7329c8dc2","abstract_canon_sha256":"52bfb5b3082a5a1ac5fbe752edcff1817459bffaa4c1472393876cb129837ef8"},"schema_version":"1.0"},"canonical_sha256":"745bf42a47ae4fc17da28f2b2a84fdec8f25e203d39f453974c337d77428439d","source":{"kind":"arxiv","id":"q-bio/0509018","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0509018","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0509018v2","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0509018","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"pith_short_12","alias_value":"ORN7IKSHVZH4","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_16","alias_value":"ORN7IKSHVZH4C7NC","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_8","alias_value":"ORN7IKSH","created_at":"2026-05-18T12:25:53Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2005:ORN7IKSHVZH4C7NCR4VSVBH55S","target":"record","payload":{"canonical_record":{"source":{"id":"q-bio/0509018","kind":"arxiv","version":2},"metadata":{"license":"","primary_cat":"q-bio.BM","submitted_at":"2005-09-15T00:17:46Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"6070492261b7ee7982184dad91fe5fee1633aa76939e57f4cab19da7329c8dc2","abstract_canon_sha256":"52bfb5b3082a5a1ac5fbe752edcff1817459bffaa4c1472393876cb129837ef8"},"schema_version":"1.0"},"canonical_sha256":"745bf42a47ae4fc17da28f2b2a84fdec8f25e203d39f453974c337d77428439d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:41:57.211028Z","signature_b64":"IArnAEQj0exbSvKNwU9uVIn+aRxtsv5SrkP276czYKga+LHw9joeXeLEEIJZc/SMrcq7icqaJ+vUxbIYQ/aLDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"745bf42a47ae4fc17da28f2b2a84fdec8f25e203d39f453974c337d77428439d","last_reissued_at":"2026-05-17T23:41:57.210243Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:41:57.210243Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"q-bio/0509018","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:41:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Z/1RZlQegp+Bh/nklvu3JaUxzBJGE2Yl/KMRKa9SWa87v8XgXKD2ERJ6qWaQIVTfBUIOBWpeDZs5xtkF0kUOBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T22:10:52.800796Z"},"content_sha256":"e6b1765bc0c482abf000f9646d6ddff230971c01de0b9980fb4ad07a406b0d95","schema_version":"1.0","event_id":"sha256:e6b1765bc0c482abf000f9646d6ddff230971c01de0b9980fb4ad07a406b0d95"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2005:ORN7IKSHVZH4C7NCR4VSVBH55S","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor","license":"","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"q-bio.BM","authors_text":"Mark S. P. Sansom, Oliver Beckstein","submitted_at":"2005-09-15T00:17:46Z","abstract_excerpt":"The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin. Cryo-electron microscopy has yielded a three dimensional structure of the nAChR in its closed state. However, the exact nature and location of the channel gate remains uncertain. Although the transmembrane pore is constricted close to its center, it is not completely occluded. Rather, the pore has a central hydrophobic zone of radiu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0509018","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:41:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Ms6gKX8lY3GCxsxO+f80pCKNTrqZRKzukfKRnV242fh5jp6IuFUm03EA9Ub34/CrZlu+lV0Ern6NHVekTjXpBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-03T22:10:52.801131Z"},"content_sha256":"b3a452cb20c70453bdbe3d4c2489db1df8272b6ab2f23b54daea2ec5431dbff0","schema_version":"1.0","event_id":"sha256:b3a452cb20c70453bdbe3d4c2489db1df8272b6ab2f23b54daea2ec5431dbff0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/bundle.json","state_url":"https://pith.science/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-03T22:10:52Z","links":{"resolver":"https://pith.science/pith/ORN7IKSHVZH4C7NCR4VSVBH55S","bundle":"https://pith.science/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/bundle.json","state":"https://pith.science/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ORN7IKSHVZH4C7NCR4VSVBH55S/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2005:ORN7IKSHVZH4C7NCR4VSVBH55S","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"52bfb5b3082a5a1ac5fbe752edcff1817459bffaa4c1472393876cb129837ef8","cross_cats_sorted":["q-bio.SC"],"license":"","primary_cat":"q-bio.BM","submitted_at":"2005-09-15T00:17:46Z","title_canon_sha256":"6070492261b7ee7982184dad91fe5fee1633aa76939e57f4cab19da7329c8dc2"},"schema_version":"1.0","source":{"id":"q-bio/0509018","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0509018","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0509018v2","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0509018","created_at":"2026-05-17T23:41:57Z"},{"alias_kind":"pith_short_12","alias_value":"ORN7IKSHVZH4","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_16","alias_value":"ORN7IKSHVZH4C7NC","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_8","alias_value":"ORN7IKSH","created_at":"2026-05-18T12:25:53Z"}],"graph_snapshots":[{"event_id":"sha256:b3a452cb20c70453bdbe3d4c2489db1df8272b6ab2f23b54daea2ec5431dbff0","target":"graph","created_at":"2026-05-17T23:41:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin. Cryo-electron microscopy has yielded a three dimensional structure of the nAChR in its closed state. However, the exact nature and location of the channel gate remains uncertain. Although the transmembrane pore is constricted close to its center, it is not completely occluded. Rather, the pore has a central hydrophobic zone of radiu","authors_text":"Mark S. P. Sansom, Oliver Beckstein","cross_cats":["q-bio.SC"],"headline":"","license":"","primary_cat":"q-bio.BM","submitted_at":"2005-09-15T00:17:46Z","title":"A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0509018","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e6b1765bc0c482abf000f9646d6ddff230971c01de0b9980fb4ad07a406b0d95","target":"record","created_at":"2026-05-17T23:41:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"52bfb5b3082a5a1ac5fbe752edcff1817459bffaa4c1472393876cb129837ef8","cross_cats_sorted":["q-bio.SC"],"license":"","primary_cat":"q-bio.BM","submitted_at":"2005-09-15T00:17:46Z","title_canon_sha256":"6070492261b7ee7982184dad91fe5fee1633aa76939e57f4cab19da7329c8dc2"},"schema_version":"1.0","source":{"id":"q-bio/0509018","kind":"arxiv","version":2}},"canonical_sha256":"745bf42a47ae4fc17da28f2b2a84fdec8f25e203d39f453974c337d77428439d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"745bf42a47ae4fc17da28f2b2a84fdec8f25e203d39f453974c337d77428439d","first_computed_at":"2026-05-17T23:41:57.210243Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:41:57.210243Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"IArnAEQj0exbSvKNwU9uVIn+aRxtsv5SrkP276czYKga+LHw9joeXeLEEIJZc/SMrcq7icqaJ+vUxbIYQ/aLDA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:41:57.211028Z","signed_message":"canonical_sha256_bytes"},"source_id":"q-bio/0509018","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e6b1765bc0c482abf000f9646d6ddff230971c01de0b9980fb4ad07a406b0d95","sha256:b3a452cb20c70453bdbe3d4c2489db1df8272b6ab2f23b54daea2ec5431dbff0"],"state_sha256":"166be2f48093a5fbf508d3af3adca2cd657c59377546fea81cdcb41802e6786e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"s5uGjS4G6yphS70bUaG8yrKBk5HXDVo1K5fbpU/FNOAS71/nQd62qP5v+BcRwvSEHQZJqbMHpTcztxsWkYYwAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-03T22:10:52.802975Z","bundle_sha256":"035b3d62134f2d12a0260516936268ced5ddec3c43302e0458a6d59b123f9ebe"}}