{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:OWB34C2PYC7WFEMMRRORP6RVFR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b0b54c699a2ba9df7c534d8a0dde0d1b737b2557296308b7c4c0bd22999b24ed","cross_cats_sorted":["cs.AI","cs.SI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2021-10-28T13:10:25Z","title_canon_sha256":"96f1d2634fe07d0495e144fc9daa607f3f5805e11fc8318088148a501900ed3b"},"schema_version":"1.0","source":{"id":"2110.15087","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2110.15087","created_at":"2026-07-05T04:46:33Z"},{"alias_kind":"arxiv_version","alias_value":"2110.15087v3","created_at":"2026-07-05T04:46:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2110.15087","created_at":"2026-07-05T04:46:33Z"},{"alias_kind":"pith_short_12","alias_value":"OWB34C2PYC7W","created_at":"2026-07-05T04:46:33Z"},{"alias_kind":"pith_short_16","alias_value":"OWB34C2PYC7WFEMM","created_at":"2026-07-05T04:46:33Z"},{"alias_kind":"pith_short_8","alias_value":"OWB34C2P","created_at":"2026-07-05T04:46:33Z"}],"graph_snapshots":[{"event_id":"sha256:3cb1dbf6b14d791dc19df8641ba8d56e14eb29456accd2d22832b05feb6da93d","target":"graph","created_at":"2026-07-05T04:46:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2110.15087/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"We propose the molecular omics network (MOOMIN) a multimodal graph neural network used by AstraZeneca oncologists to predict the synergy of drug combinations for cancer treatment. Our model learns drug representations at multiple scales based on a drug-protein interaction network and metadata. Structural properties of compounds and proteins are encoded to create vertex features for a message-passing scheme that operates on the bipartite interaction graph. Propagated messages form multi-resolution drug representations which we utilized to create drug pair descriptors. By conditioning the drug c","authors_text":"Andriy Nikolov, Anna Gogleva, Benedek Rozemberczki, Eliseo Papa, Gavin Edwards, Sebastian Nilsson","cross_cats":["cs.AI","cs.SI"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2021-10-28T13:10:25Z","title":"MOOMIN: Deep Molecular Omics Network for Anti-Cancer Drug Combination Therapy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2110.15087","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d34f0bae0c199072c88342c698758ff6a01cb3bf77dc4935f3d0f5117cd0c302","target":"record","created_at":"2026-07-05T04:46:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b0b54c699a2ba9df7c534d8a0dde0d1b737b2557296308b7c4c0bd22999b24ed","cross_cats_sorted":["cs.AI","cs.SI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2021-10-28T13:10:25Z","title_canon_sha256":"96f1d2634fe07d0495e144fc9daa607f3f5805e11fc8318088148a501900ed3b"},"schema_version":"1.0","source":{"id":"2110.15087","kind":"arxiv","version":3}},"canonical_sha256":"7583be0b4fc0bf62918c8c5d17fa352c75c1a73ccad80fab122f9de74b785b2a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7583be0b4fc0bf62918c8c5d17fa352c75c1a73ccad80fab122f9de74b785b2a","first_computed_at":"2026-07-05T04:46:33.419025Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:46:33.419025Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"DVdX+85Vtc4ti9XjL9xia/fray34tQ7NWRwZfrB1cl/VCfyMXAaD7Y4kN3sWEd0OouMDdnQt0Iix+ToIvwI/DQ==","signature_status":"signed_v1","signed_at":"2026-07-05T04:46:33.419469Z","signed_message":"canonical_sha256_bytes"},"source_id":"2110.15087","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d34f0bae0c199072c88342c698758ff6a01cb3bf77dc4935f3d0f5117cd0c302","sha256:3cb1dbf6b14d791dc19df8641ba8d56e14eb29456accd2d22832b05feb6da93d"],"state_sha256":"e835b2a868337b247071b2c94a15a497d7e00333c51e776a0acbb3af72cee30f"}