{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:P3QVZL6CNXBMBWUUTZJUANIM4C","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"687024c7adbbcadcf16586bdc3dce371b3f3a69bf3c3a5c865480de7f39c782f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-12-08T22:33:58Z","title_canon_sha256":"1cc3415e17a256cc8bee43651c2efa451197064ec309f4561fe258db4b14d7ef"},"schema_version":"1.0","source":{"id":"0912.1627","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0912.1627","created_at":"2026-05-18T04:35:47Z"},{"alias_kind":"arxiv_version","alias_value":"0912.1627v1","created_at":"2026-05-18T04:35:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0912.1627","created_at":"2026-05-18T04:35:47Z"},{"alias_kind":"pith_short_12","alias_value":"P3QVZL6CNXBM","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"P3QVZL6CNXBMBWUU","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"P3QVZL6C","created_at":"2026-05-18T12:26:01Z"}],"graph_snapshots":[{"event_id":"sha256:ce60d15598d5bae5acc9a73cdbf5ca1d2c21464123d60fe33e2b401c080c3ad3","target":"graph","created_at":"2026-05-18T04:35:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the current study, we provide a novel mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendous variation in the rate of tumor devel","authors_text":"Bert Vogelstein, Dewey Kim, Hannah Carter, Hisashi Ohtsuki, Ivana Bozic, Kenneth W. Kinzler, Martin A. Nowak, Rachel Karchin, Sining Chen, Tibor Antal","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-12-08T22:33:58Z","title":"Accumulation of driver and passenger mutations during tumor progression"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0912.1627","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1388563709555db51e94bbf751384ab0a37809e425d633ee74f982e9a42803b5","target":"record","created_at":"2026-05-18T04:35:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"687024c7adbbcadcf16586bdc3dce371b3f3a69bf3c3a5c865480de7f39c782f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-12-08T22:33:58Z","title_canon_sha256":"1cc3415e17a256cc8bee43651c2efa451197064ec309f4561fe258db4b14d7ef"},"schema_version":"1.0","source":{"id":"0912.1627","kind":"arxiv","version":1}},"canonical_sha256":"7ee15cafc26dc2c0da949e5340350ce09a0ebed11c998a332dee3aea99967a00","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7ee15cafc26dc2c0da949e5340350ce09a0ebed11c998a332dee3aea99967a00","first_computed_at":"2026-05-18T04:35:47.824738Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:35:47.824738Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"tjge9IlaOg60R7OxfXMwdSPAw7REq1h9tYYDWykWyrQrkpZopDueG2cEzMnrNT80a6m6HeTS96Wjzfzd1IUfAw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:35:47.825382Z","signed_message":"canonical_sha256_bytes"},"source_id":"0912.1627","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1388563709555db51e94bbf751384ab0a37809e425d633ee74f982e9a42803b5","sha256:ce60d15598d5bae5acc9a73cdbf5ca1d2c21464123d60fe33e2b401c080c3ad3"],"state_sha256":"4fedffa7f92b8f0795fa7e25022d339da0689f0716c75db75e6e47e1e15bfd69"}