{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:Q7UMQA6F3NCCWWGSJ6MAMJK7DO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fcd0290ad4fc322884d6ed0f71918694fc54edb19138fd6e3c5f6d467736c833","cross_cats_sorted":["q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-12-19T21:17:21Z","title_canon_sha256":"e9c3acf6a67c99678252daa7d2cdf4ea4422a12409af63c0cddfc9316ea6a892"},"schema_version":"1.0","source":{"id":"1812.08248","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.08248","created_at":"2026-05-17T23:57:50Z"},{"alias_kind":"arxiv_version","alias_value":"1812.08248v1","created_at":"2026-05-17T23:57:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.08248","created_at":"2026-05-17T23:57:50Z"},{"alias_kind":"pith_short_12","alias_value":"Q7UMQA6F3NCC","created_at":"2026-05-18T12:32:46Z"},{"alias_kind":"pith_short_16","alias_value":"Q7UMQA6F3NCCWWGS","created_at":"2026-05-18T12:32:46Z"},{"alias_kind":"pith_short_8","alias_value":"Q7UMQA6F","created_at":"2026-05-18T12:32:46Z"}],"graph_snapshots":[{"event_id":"sha256:5f1026b027bfd823db65ee32ad27d771ce801e89aa694d08dfc90be730b6be37","target":"graph","created_at":"2026-05-17T23:57:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca2+ and K+ homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to dir","authors_text":"Attilio Marino, Christos Tapeinos, Enrico Almici, Francesco Saverio Pavone, Gianni Ciofani, Giuseppe de Vito, Marco Marchetti, Matteo Battaglini, Riccardo Cicchi, Simone Migliorin, Valentina Cappello","cross_cats":["q-bio.TO"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-12-19T21:17:21Z","title":"Piezoelectric Barium Titanate Nanostimulators for the Treatment of Glioblastoma Multiforme"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.08248","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8a864f0c28392a2c18551d4aa8bc3811bd4f38273fc7859f6865054796ff440d","target":"record","created_at":"2026-05-17T23:57:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fcd0290ad4fc322884d6ed0f71918694fc54edb19138fd6e3c5f6d467736c833","cross_cats_sorted":["q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-12-19T21:17:21Z","title_canon_sha256":"e9c3acf6a67c99678252daa7d2cdf4ea4422a12409af63c0cddfc9316ea6a892"},"schema_version":"1.0","source":{"id":"1812.08248","kind":"arxiv","version":1}},"canonical_sha256":"87e8c803c5db442b58d24f9806255f1b8122c5299bc95b53a5f1d98eb5acd630","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"87e8c803c5db442b58d24f9806255f1b8122c5299bc95b53a5f1d98eb5acd630","first_computed_at":"2026-05-17T23:57:50.097795Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:57:50.097795Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"0A/YQYDtLV1p7AkSKMQePlR8R0tYPxuDyWpC/mx20ix5qndqVPrEg9DWHWlQPQXF+/y6+O/vvLYuaHvpePUMBg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:57:50.098533Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.08248","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8a864f0c28392a2c18551d4aa8bc3811bd4f38273fc7859f6865054796ff440d","sha256:5f1026b027bfd823db65ee32ad27d771ce801e89aa694d08dfc90be730b6be37"],"state_sha256":"35c993b4c4540afbbb9d148c3216de2f8084a0cc7a6b5d81a627122c7ef83736"}