{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2026:QROS64YGYMKSGEHGTMQEJFITZC","short_pith_number":"pith:QROS64YG","schema_version":"1.0","canonical_sha256":"845d2f7306c3152310e69b20449513c8a10abfbc32a7ead7cf1c047bace3c4a6","source":{"kind":"arxiv","id":"2606.27824","version":1},"attestation_state":"computed","paper":{"title":"Pepti-drift: Toxicity-Repulsive Drifting for Antigen-Conditioned Discrete Peptide Generation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.AI"],"primary_cat":"cs.LG","authors_text":"Hikaru Shindo, Jun Jin Choong, Kaushalya Madhawa, Keisuke Ozawa, Takashi Fujiwara","submitted_at":"2026-06-26T08:04:11Z","abstract_excerpt":"Peptides are a promising therapeutic modality that combine the chemical tunability of small molecules with the target specificity of macromolecular therapeutics. However, designing antigen-specific binding peptides while avoiding toxicity remains a major challenge for therapeutic peptide discovery. Here, we present Pepti-drift, a toxicity-aware latent refinement framework that generates peptide candidates through a single antigen-conditioned drift step. In a peptide embedding space, Pepti-drift learns to attract generated peptide latents toward antigen-matched binding peptides while repelling "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2606.27824","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-06-26T08:04:11Z","cross_cats_sorted":["cs.AI"],"title_canon_sha256":"65580034ccfeb4bebd3194fb7ede742dd53ef8a88ff67c1f948bec173261c4e8","abstract_canon_sha256":"b5f8fcf69907ffc44fd5441926b26ce39627ba5fefe1c9298bfa1b1b81836726"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-29T01:14:49.515183Z","signature_b64":"tErxwqu73rOzHE8Qjcfq5iwlQFqlnW+qq4+M5TapB8a3kiXP3d95tJTHcTBSKMwy22vlzYWII98TSynSZK1PDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"845d2f7306c3152310e69b20449513c8a10abfbc32a7ead7cf1c047bace3c4a6","last_reissued_at":"2026-06-29T01:14:49.514768Z","signature_status":"signed_v1","first_computed_at":"2026-06-29T01:14:49.514768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Pepti-drift: Toxicity-Repulsive Drifting for Antigen-Conditioned Discrete Peptide Generation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.AI"],"primary_cat":"cs.LG","authors_text":"Hikaru Shindo, Jun Jin Choong, Kaushalya Madhawa, Keisuke Ozawa, Takashi Fujiwara","submitted_at":"2026-06-26T08:04:11Z","abstract_excerpt":"Peptides are a promising therapeutic modality that combine the chemical tunability of small molecules with the target specificity of macromolecular therapeutics. However, designing antigen-specific binding peptides while avoiding toxicity remains a major challenge for therapeutic peptide discovery. Here, we present Pepti-drift, a toxicity-aware latent refinement framework that generates peptide candidates through a single antigen-conditioned drift step. In a peptide embedding space, Pepti-drift learns to attract generated peptide latents toward antigen-matched binding peptides while repelling "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.27824","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.27824/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2606.27824","created_at":"2026-06-29T01:14:49.514832+00:00"},{"alias_kind":"arxiv_version","alias_value":"2606.27824v1","created_at":"2026-06-29T01:14:49.514832+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.27824","created_at":"2026-06-29T01:14:49.514832+00:00"},{"alias_kind":"pith_short_12","alias_value":"QROS64YGYMKS","created_at":"2026-06-29T01:14:49.514832+00:00"},{"alias_kind":"pith_short_16","alias_value":"QROS64YGYMKSGEHG","created_at":"2026-06-29T01:14:49.514832+00:00"},{"alias_kind":"pith_short_8","alias_value":"QROS64YG","created_at":"2026-06-29T01:14:49.514832+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC","json":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC.json","graph_json":"https://pith.science/api/pith-number/QROS64YGYMKSGEHGTMQEJFITZC/graph.json","events_json":"https://pith.science/api/pith-number/QROS64YGYMKSGEHGTMQEJFITZC/events.json","paper":"https://pith.science/paper/QROS64YG"},"agent_actions":{"view_html":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC","download_json":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC.json","view_paper":"https://pith.science/paper/QROS64YG","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2606.27824&json=true","fetch_graph":"https://pith.science/api/pith-number/QROS64YGYMKSGEHGTMQEJFITZC/graph.json","fetch_events":"https://pith.science/api/pith-number/QROS64YGYMKSGEHGTMQEJFITZC/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC/action/timestamp_anchor","attest_storage":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC/action/storage_attestation","attest_author":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC/action/author_attestation","sign_citation":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC/action/citation_signature","submit_replication":"https://pith.science/pith/QROS64YGYMKSGEHGTMQEJFITZC/action/replication_record"}},"created_at":"2026-06-29T01:14:49.514832+00:00","updated_at":"2026-06-29T01:14:49.514832+00:00"}