{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:SNWX7ASBT5IWJKSQDFW7N2SSFC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ff021b48fb83fbc77f93ab2f3c49cae44a02e3f863b554349405f4ef05f1d46e","cross_cats_sorted":["cs.AI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2026-06-23T16:37:48Z","title_canon_sha256":"12cc7d51bfdb6be533bb6c532970808c39ae95b3d9331fb203379777cca73ca0"},"schema_version":"1.0","source":{"id":"2606.24779","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.24779","created_at":"2026-06-24T01:15:42Z"},{"alias_kind":"arxiv_version","alias_value":"2606.24779v1","created_at":"2026-06-24T01:15:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.24779","created_at":"2026-06-24T01:15:42Z"},{"alias_kind":"pith_short_12","alias_value":"SNWX7ASBT5IW","created_at":"2026-06-24T01:15:42Z"},{"alias_kind":"pith_short_16","alias_value":"SNWX7ASBT5IWJKSQ","created_at":"2026-06-24T01:15:42Z"},{"alias_kind":"pith_short_8","alias_value":"SNWX7ASB","created_at":"2026-06-24T01:15:42Z"}],"graph_snapshots":[{"event_id":"sha256:26dc5340716eca871856dd730d23f3aa1441ff14554e7e30dec4a9dba504e40b","target":"graph","created_at":"2026-06-24T01:15:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.24779/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Birth defects are a major cause of fetal loss, neonatal morbidity and long-term disability. In the subset with suspected genetic etiologies, exome and genome sequencing have moved many cases from variant detection to post-sequencing interpretation: clinicians must rank patient-specific candidate variants under incomplete fetal or infant phenotypes and heterogeneous evidence from population genetics, variant-effect prediction, gene-disease validity, phenotype ontologies, cellular and pathway context, protein structure and clinical literature. We present DeepBD, a grounded agentic workflow for v","authors_text":"Genjie Li, Haishuai Wang, Jiajun Bu, Jiajun Yu, Jielong Lu, Shiyu Li, Weiran Liao, Zeyu Chu, Zhihao Wu, Ziqi Yan","cross_cats":["cs.AI"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2026-06-23T16:37:48Z","title":"DeepBD: A Grounded Agentic Workflow for Variant Prioritization and Diagnosis of Genetic Birth Defects"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.24779","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bd39758b8e4a7a80996a9befbfca4e343bc1b641c719eaedefbedea43005d39d","target":"record","created_at":"2026-06-24T01:15:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ff021b48fb83fbc77f93ab2f3c49cae44a02e3f863b554349405f4ef05f1d46e","cross_cats_sorted":["cs.AI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2026-06-23T16:37:48Z","title_canon_sha256":"12cc7d51bfdb6be533bb6c532970808c39ae95b3d9331fb203379777cca73ca0"},"schema_version":"1.0","source":{"id":"2606.24779","kind":"arxiv","version":1}},"canonical_sha256":"936d7f82419f5164aa50196df6ea522883ac78032e819e3c6ad105eba14130a8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"936d7f82419f5164aa50196df6ea522883ac78032e819e3c6ad105eba14130a8","first_computed_at":"2026-06-24T01:15:42.061354Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-24T01:15:42.061354Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5kB1Sw1ZhFYuos2QulObK2Qh88cueK4uJ9t9GIjwBgl4DgQ1eKvuQPn4j/cbbmqlRQWJR7S0ThN0EvcpteGVCw==","signature_status":"signed_v1","signed_at":"2026-06-24T01:15:42.061759Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.24779","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bd39758b8e4a7a80996a9befbfca4e343bc1b641c719eaedefbedea43005d39d","sha256:26dc5340716eca871856dd730d23f3aa1441ff14554e7e30dec4a9dba504e40b"],"state_sha256":"3edbf17b4146067f186552d42460d3adc218fa5f82c7a9e72c70b829bba2c3e7"}