{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:SSZNLLKICTGRXNYTLCI6IMB7OL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d5178ee7f98b4be2df322735b9c6c1be95890852aac777f8a56862acfae93160","cross_cats_sorted":["cs.AR","cs.ET","cs.NE"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-06-15T22:20:44Z","title_canon_sha256":"f8d2af465743458a20d721709c7bfdb758b8d402d0829f42f171f4cf33fce745"},"schema_version":"1.0","source":{"id":"2606.17327","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.17327","created_at":"2026-06-19T16:10:09Z"},{"alias_kind":"arxiv_version","alias_value":"2606.17327v1","created_at":"2026-06-19T16:10:09Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.17327","created_at":"2026-06-19T16:10:09Z"},{"alias_kind":"pith_short_12","alias_value":"SSZNLLKICTGR","created_at":"2026-06-19T16:10:09Z"},{"alias_kind":"pith_short_16","alias_value":"SSZNLLKICTGRXNYT","created_at":"2026-06-19T16:10:09Z"},{"alias_kind":"pith_short_8","alias_value":"SSZNLLKI","created_at":"2026-06-19T16:10:09Z"}],"graph_snapshots":[{"event_id":"sha256:830f84afa40251f271594e530609c269a799eba3357d52e7962875347d6e5bfe","target":"graph","created_at":"2026-06-19T16:10:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.17327/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The growing energy demand for computation is becoming increasingly unsustainable. Thermodynamic computing, which harnesses physical thermal fluctuations as a computational resource rather than suppressing them, offers orders-of-magnitude energy savings for probabilistic and combinatorial tasks. Pharmaceutical R&D, heavily reliant on computational optimization and sampling, is a natural application domain. Here we present what is, to our knowledge, the first concrete pharmaceutical application mapped to thermodynamic hardware with energy estimates grounded in prototype measurements. We reduce m","authors_text":"Andraz Jelincic, Ross C. Walker","cross_cats":["cs.AR","cs.ET","cs.NE"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-06-15T22:20:44Z","title":"Energy-efficient codon optimization on thermodynamic hardware"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.17327","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:664c0fcface4008d152520498b74c48be53d606fdcd06fc1cab8c075168f1935","target":"record","created_at":"2026-06-19T16:10:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d5178ee7f98b4be2df322735b9c6c1be95890852aac777f8a56862acfae93160","cross_cats_sorted":["cs.AR","cs.ET","cs.NE"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-06-15T22:20:44Z","title_canon_sha256":"f8d2af465743458a20d721709c7bfdb758b8d402d0829f42f171f4cf33fce745"},"schema_version":"1.0","source":{"id":"2606.17327","kind":"arxiv","version":1}},"canonical_sha256":"94b2d5ad4814cd1bb7135891e4303f72c006416862d88fbdbddab49a26bfb668","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"94b2d5ad4814cd1bb7135891e4303f72c006416862d88fbdbddab49a26bfb668","first_computed_at":"2026-06-19T16:10:09.342885Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-19T16:10:09.342885Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NZTwwMLwESgRgXvrqqd6I4W+O+Q+IOf0zgk2o01vj6ZF3tkslqa+X4Ou38cBQB9+4qUrcW5ikl036AsmSGOkCA==","signature_status":"signed_v1","signed_at":"2026-06-19T16:10:09.343221Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.17327","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:664c0fcface4008d152520498b74c48be53d606fdcd06fc1cab8c075168f1935","sha256:830f84afa40251f271594e530609c269a799eba3357d52e7962875347d6e5bfe"],"state_sha256":"388e73af34edd8769eef058f3b2b5d9a68e5f6b3946e8004dda11b20e879545f"}