{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:SUNSTH5E32G756UA7JY4Y72ZBE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c65bca31f3fddfb35e843cd4ca202d703dd034e2bb5a99c713a9551d4faaa8c1","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-04-06T18:21:19Z","title_canon_sha256":"29ed5a739be9e40568d4fdf576fe11eedc6b12d3b2fcf6ff74405e2b7a5a0fc9"},"schema_version":"1.0","source":{"id":"1604.01715","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1604.01715","created_at":"2026-05-18T00:51:25Z"},{"alias_kind":"arxiv_version","alias_value":"1604.01715v1","created_at":"2026-05-18T00:51:25Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1604.01715","created_at":"2026-05-18T00:51:25Z"},{"alias_kind":"pith_short_12","alias_value":"SUNSTH5E32G7","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_16","alias_value":"SUNSTH5E32G756UA","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_8","alias_value":"SUNSTH5E","created_at":"2026-05-18T12:30:44Z"}],"graph_snapshots":[{"event_id":"sha256:e0dc5cdbeffb9d389c84b03c8f6876bb5f22a3538afb6235f2bf7f97323a1618","target":"graph","created_at":"2026-05-18T00:51:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Tumours develop in an evolutionary process, in which the accumulation of mutations produces subpopulations of cells with distinct mutational profiles, called clones. This process leads to the genetic heterogeneity widely observed in tumour sequencing data, but identifying the genotypes and frequencies of the different clones is still a major challenge. Here, we present Cloe, a phylogenetic latent feature model to deconvolute tumour sequencing data into a set of related genotypes. Our approach extends latent feature models by placing the features as nodes in a latent tree. The resulting model c","authors_text":"Florent Mouliere, Florian Markowetz, Francesco Marass, Ke Yuan, Nitzan Rosenfeld","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-04-06T18:21:19Z","title":"A phylogenetic latent feature model for clonal deconvolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1604.01715","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1c3c66afed002ba0e7d307917161cfd49a30d13ab5d5f4b9423bf662e8c9187b","target":"record","created_at":"2026-05-18T00:51:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c65bca31f3fddfb35e843cd4ca202d703dd034e2bb5a99c713a9551d4faaa8c1","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-04-06T18:21:19Z","title_canon_sha256":"29ed5a739be9e40568d4fdf576fe11eedc6b12d3b2fcf6ff74405e2b7a5a0fc9"},"schema_version":"1.0","source":{"id":"1604.01715","kind":"arxiv","version":1}},"canonical_sha256":"951b299fa4de8dfefa80fa71cc7f590930a2b871ed50f2a41a03e169e74a69b0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"951b299fa4de8dfefa80fa71cc7f590930a2b871ed50f2a41a03e169e74a69b0","first_computed_at":"2026-05-18T00:51:25.725142Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:51:25.725142Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"PMe1ZGiBRsDqth/8gGx3vAOKhysDBdNw5dttGFkqkLC9A6RJ1OYcTXL1t6uRG4cKSsimu3K7+N1AypL6uf35AA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:51:25.725697Z","signed_message":"canonical_sha256_bytes"},"source_id":"1604.01715","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1c3c66afed002ba0e7d307917161cfd49a30d13ab5d5f4b9423bf662e8c9187b","sha256:e0dc5cdbeffb9d389c84b03c8f6876bb5f22a3538afb6235f2bf7f97323a1618"],"state_sha256":"6ebbad7ce8f70a15d1309e7dba57011170ad3f7f58ceb1f92bc5c7c38e2c0b10"}