{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2008:SWF4JRH6ZNEWO4GRFUHOQDP2V5","short_pith_number":"pith:SWF4JRH6","canonical_record":{"source":{"id":"0807.3638","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2008-07-23T14:23:52Z","cross_cats_sorted":[],"title_canon_sha256":"41f8ab9043d88430d9f2bb34d4750b524e677dda4920e354bbd7eeede658cfe0","abstract_canon_sha256":"a1668d990edacb295aae0805b7989e5097038d3011deae17adec6eaea4c230d1"},"schema_version":"1.0"},"canonical_sha256":"958bc4c4fecb496770d12d0ee80dfaaf6a00b1261150374116a4e3275da07953","source":{"kind":"arxiv","id":"0807.3638","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0807.3638","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"arxiv_version","alias_value":"0807.3638v2","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0807.3638","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"pith_short_12","alias_value":"SWF4JRH6ZNEW","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_16","alias_value":"SWF4JRH6ZNEWO4GR","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_8","alias_value":"SWF4JRH6","created_at":"2026-05-18T12:25:58Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2008:SWF4JRH6ZNEWO4GRFUHOQDP2V5","target":"record","payload":{"canonical_record":{"source":{"id":"0807.3638","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2008-07-23T14:23:52Z","cross_cats_sorted":[],"title_canon_sha256":"41f8ab9043d88430d9f2bb34d4750b524e677dda4920e354bbd7eeede658cfe0","abstract_canon_sha256":"a1668d990edacb295aae0805b7989e5097038d3011deae17adec6eaea4c230d1"},"schema_version":"1.0"},"canonical_sha256":"958bc4c4fecb496770d12d0ee80dfaaf6a00b1261150374116a4e3275da07953","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:14:36.462817Z","signature_b64":"5EXkOhRgfb3kUgn7dB4+KNy+3vOUstBW6TfXSVV5l1OphRpROnSJef6FBbYEfJlUrGdGsouguwe/PWY0CInECw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"958bc4c4fecb496770d12d0ee80dfaaf6a00b1261150374116a4e3275da07953","last_reissued_at":"2026-05-18T04:14:36.462187Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:14:36.462187Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0807.3638","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:14:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aqL+TwFIRfYILaXztPtefUgNQBKs1nCKbB3D3xE1sbm/WG+X/rY/4ATKOyQ1CnzBZi2y9K88GvtyZQN48UoGBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T08:15:29.017675Z"},"content_sha256":"61a1d8419e2c7cfe618490e93e6619304f9f4f8a1aeb66ce26d4b58d737a97c2","schema_version":"1.0","event_id":"sha256:61a1d8419e2c7cfe618490e93e6619304f9f4f8a1aeb66ce26d4b58d737a97c2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2008:SWF4JRH6ZNEWO4GRFUHOQDP2V5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Waiting time models of cancer progression","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Moritz Gerstung, Niko Beerenwinkel","submitted_at":"2008-07-23T14:23:52Z","abstract_excerpt":"Cancer progression is an evolutionary process that is driven by mutation and selection in a population of tumor cells. We discuss mathematical models of cancer progression, starting from traditional multistage theory. Each stage is associated with the occurrence of genetic alterations and their fixation in the population. We describe the accumulation of mutations using conjunctive Bayesian networks, an exponential family of waiting time models in which the occurrence of mutations is constrained to a partial temporal order. Two opposing limit cases arise if mutations either follow a linear orde"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0807.3638","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:14:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lh7kvDN3H9Q4/EPwzpr+k4u2uudFQ4ah4QtKMesvXRaA484E7NGXNsVqAHWWDG0rumIDad6NTBkAE38d+eKoBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-01T08:15:29.018260Z"},"content_sha256":"396dff3dd0877285e2a7302968c02cb1a441f92ba84e58c646a5610072cb6d27","schema_version":"1.0","event_id":"sha256:396dff3dd0877285e2a7302968c02cb1a441f92ba84e58c646a5610072cb6d27"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/bundle.json","state_url":"https://pith.science/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-01T08:15:29Z","links":{"resolver":"https://pith.science/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5","bundle":"https://pith.science/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/bundle.json","state":"https://pith.science/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SWF4JRH6ZNEWO4GRFUHOQDP2V5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2008:SWF4JRH6ZNEWO4GRFUHOQDP2V5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a1668d990edacb295aae0805b7989e5097038d3011deae17adec6eaea4c230d1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2008-07-23T14:23:52Z","title_canon_sha256":"41f8ab9043d88430d9f2bb34d4750b524e677dda4920e354bbd7eeede658cfe0"},"schema_version":"1.0","source":{"id":"0807.3638","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0807.3638","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"arxiv_version","alias_value":"0807.3638v2","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0807.3638","created_at":"2026-05-18T04:14:36Z"},{"alias_kind":"pith_short_12","alias_value":"SWF4JRH6ZNEW","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_16","alias_value":"SWF4JRH6ZNEWO4GR","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_8","alias_value":"SWF4JRH6","created_at":"2026-05-18T12:25:58Z"}],"graph_snapshots":[{"event_id":"sha256:396dff3dd0877285e2a7302968c02cb1a441f92ba84e58c646a5610072cb6d27","target":"graph","created_at":"2026-05-18T04:14:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cancer progression is an evolutionary process that is driven by mutation and selection in a population of tumor cells. We discuss mathematical models of cancer progression, starting from traditional multistage theory. Each stage is associated with the occurrence of genetic alterations and their fixation in the population. We describe the accumulation of mutations using conjunctive Bayesian networks, an exponential family of waiting time models in which the occurrence of mutations is constrained to a partial temporal order. Two opposing limit cases arise if mutations either follow a linear orde","authors_text":"Moritz Gerstung, Niko Beerenwinkel","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2008-07-23T14:23:52Z","title":"Waiting time models of cancer progression"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0807.3638","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:61a1d8419e2c7cfe618490e93e6619304f9f4f8a1aeb66ce26d4b58d737a97c2","target":"record","created_at":"2026-05-18T04:14:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a1668d990edacb295aae0805b7989e5097038d3011deae17adec6eaea4c230d1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2008-07-23T14:23:52Z","title_canon_sha256":"41f8ab9043d88430d9f2bb34d4750b524e677dda4920e354bbd7eeede658cfe0"},"schema_version":"1.0","source":{"id":"0807.3638","kind":"arxiv","version":2}},"canonical_sha256":"958bc4c4fecb496770d12d0ee80dfaaf6a00b1261150374116a4e3275da07953","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"958bc4c4fecb496770d12d0ee80dfaaf6a00b1261150374116a4e3275da07953","first_computed_at":"2026-05-18T04:14:36.462187Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:14:36.462187Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5EXkOhRgfb3kUgn7dB4+KNy+3vOUstBW6TfXSVV5l1OphRpROnSJef6FBbYEfJlUrGdGsouguwe/PWY0CInECw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:14:36.462817Z","signed_message":"canonical_sha256_bytes"},"source_id":"0807.3638","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:61a1d8419e2c7cfe618490e93e6619304f9f4f8a1aeb66ce26d4b58d737a97c2","sha256:396dff3dd0877285e2a7302968c02cb1a441f92ba84e58c646a5610072cb6d27"],"state_sha256":"0d6112856c8d13b08a5bb2b8948ecf379d45ce813c4fe07924186e6bc0fd34c8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"79u93KeNds49kQUBEfGd6U7aG23/2Rc3JJ2txCFVZigjivpIdzz9Ww39WWaklXWRCy8VbgsUdC3J4G6uItB9AA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-01T08:15:29.022050Z","bundle_sha256":"e14e8042932ceea9e9a993b69fbd05e295b9c8f6bd99979ed4bf29fc04fd0221"}}