{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:TSSAZ76GQMOTVD3NXGMYI2MR42","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f56e8dc239d9e76c9b5c2b8999ff2e468bffe9b994082cea736d1c757f0d40ab","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-07T15:30:01Z","title_canon_sha256":"37295f48c92182bbe29a19f600d83859054a6535d156727227798825d4d7fa0d"},"schema_version":"1.0","source":{"id":"1202.1447","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.1447","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"arxiv_version","alias_value":"1202.1447v1","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.1447","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"pith_short_12","alias_value":"TSSAZ76GQMOT","created_at":"2026-05-18T12:27:23Z"},{"alias_kind":"pith_short_16","alias_value":"TSSAZ76GQMOTVD3N","created_at":"2026-05-18T12:27:23Z"},{"alias_kind":"pith_short_8","alias_value":"TSSAZ76G","created_at":"2026-05-18T12:27:23Z"}],"graph_snapshots":[{"event_id":"sha256:fac0e0367dc25e5cd277424c73b63f7acd97ec72741feaeb911ffbef5a95166c","target":"graph","created_at":"2026-05-18T04:00:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple model gene promoter in response to oscillating and constant transcription factor signals. We find that in biologically-relevant parameter regimes an oscillating input can produce a more constant protein level than a constant input. Our results suggest that oscillating signals may be used to minimize noise in gene regulation.","authors_text":"Filipe Tostevin, Pieter Rein ten Wolde, Wiet de Ronde","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-07T15:30:01Z","title":"Reliability of frequency- and amplitude-decoding in gene regulation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.1447","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4ac428a0a17c2483ee953355af744fd08059e54c36b94cb3e5efd93130c388f1","target":"record","created_at":"2026-05-18T04:00:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f56e8dc239d9e76c9b5c2b8999ff2e468bffe9b994082cea736d1c757f0d40ab","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-07T15:30:01Z","title_canon_sha256":"37295f48c92182bbe29a19f600d83859054a6535d156727227798825d4d7fa0d"},"schema_version":"1.0","source":{"id":"1202.1447","kind":"arxiv","version":1}},"canonical_sha256":"9ca40cffc6831d3a8f6db999846991e685d06774975b6120e031884b063adbce","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9ca40cffc6831d3a8f6db999846991e685d06774975b6120e031884b063adbce","first_computed_at":"2026-05-18T04:00:37.597603Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:00:37.597603Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ssfV8pxGEe2zHW1JxePjiWfRxz0rGGFxTRoXUx2fDWpxMeZCoULPTMq59lWmWQeQH82dsMe7d/+ECpb5sJwqDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T04:00:37.598333Z","signed_message":"canonical_sha256_bytes"},"source_id":"1202.1447","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4ac428a0a17c2483ee953355af744fd08059e54c36b94cb3e5efd93130c388f1","sha256:fac0e0367dc25e5cd277424c73b63f7acd97ec72741feaeb911ffbef5a95166c"],"state_sha256":"12c77df48e9b6ba1b94bb3ba3a0e2607f7235a70de783bc9eb2362803e3fffcb"}