{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:UXVVKLSYGSRWZGWOMVNBSD7PXE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d03e3d5efbb5d649e5f4357c3e2b85ef9fb82c6309a0bc062da2bb9711a94f1b","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2026-06-23T08:04:33Z","title_canon_sha256":"cd4e0d1ca93fc507bc8e7db4013d6de6c1a2fee0cba3fe14416053c897b75e7d"},"schema_version":"1.0","source":{"id":"2606.24283","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.24283","created_at":"2026-06-24T01:14:48Z"},{"alias_kind":"arxiv_version","alias_value":"2606.24283v1","created_at":"2026-06-24T01:14:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.24283","created_at":"2026-06-24T01:14:48Z"},{"alias_kind":"pith_short_12","alias_value":"UXVVKLSYGSRW","created_at":"2026-06-24T01:14:48Z"},{"alias_kind":"pith_short_16","alias_value":"UXVVKLSYGSRWZGWO","created_at":"2026-06-24T01:14:48Z"},{"alias_kind":"pith_short_8","alias_value":"UXVVKLSY","created_at":"2026-06-24T01:14:48Z"}],"graph_snapshots":[{"event_id":"sha256:559bd660f0bec4c00d04d58d5ac817467dbb0d170b952c0d45dc0a02ec5e3cca","target":"graph","created_at":"2026-06-24T01:14:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.24283/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Principal component analysis (PCA) is widely used to characterize collective protein motions from molecular dynamics (MD) simulations. While PCA identifies the dominant modes of structural fluctuation, it does not reveal whether different principal components (PCs) causally influence each other. Here, we investigate this question using a recently introduced causal-discovery framework [Del Tatto et al, PNAS 2024], which allows to infer putative causal asymmetries between high-dimensional time series. We apply this approach to long-timescale MD trajectories of two proteins. By analyzing relation","authors_text":"Alessandro Laio, Ali Hassanali, Debarshi Banerjee","cross_cats":["cond-mat.stat-mech","physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2026-06-23T08:04:33Z","title":"Investigating causality between principal components in protein dynamics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.24283","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:54bffb23c88f375df9601ed9b3e41ff57d740bf7dcc45464071fe13717dc7ec7","target":"record","created_at":"2026-06-24T01:14:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d03e3d5efbb5d649e5f4357c3e2b85ef9fb82c6309a0bc062da2bb9711a94f1b","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2026-06-23T08:04:33Z","title_canon_sha256":"cd4e0d1ca93fc507bc8e7db4013d6de6c1a2fee0cba3fe14416053c897b75e7d"},"schema_version":"1.0","source":{"id":"2606.24283","kind":"arxiv","version":1}},"canonical_sha256":"a5eb552e5834a36c9ace655a190fefb92681db70aaefbf8b30beddb047969c14","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a5eb552e5834a36c9ace655a190fefb92681db70aaefbf8b30beddb047969c14","first_computed_at":"2026-06-24T01:14:48.937568Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-24T01:14:48.937568Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vItRUAoEF8yVN7lJ8pp44eFT3ljZQeEIATRCg+phPnphGFxpB4yuPQgFgkbAqkAmOr88lUv1fukWURfQnKKEDg==","signature_status":"signed_v1","signed_at":"2026-06-24T01:14:48.937930Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.24283","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:54bffb23c88f375df9601ed9b3e41ff57d740bf7dcc45464071fe13717dc7ec7","sha256:559bd660f0bec4c00d04d58d5ac817467dbb0d170b952c0d45dc0a02ec5e3cca"],"state_sha256":"a1c15bda156385c0223dcec3cb93f42acd70831caa8053bcd2489a50c14e3315"}