{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2008:VMUVYFXHZDGZXLWU5WEYWDLO2V","short_pith_number":"pith:VMUVYFXH","canonical_record":{"source":{"id":"0807.0247","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2008-07-01T22:01:21Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"58ea2c9360b8068236cff920fada9397f786a6cdfc5fd5eeee8ba39eb4a6daef","abstract_canon_sha256":"b93fb8cf527959983d537b229f92405f1af7f5981921aab730ff161213dee1fd"},"schema_version":"1.0"},"canonical_sha256":"ab295c16e7c8cd9baed4ed898b0d6ed5680090c4af92049d049fff3cd981b531","source":{"kind":"arxiv","id":"0807.0247","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0807.0247","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"arxiv_version","alias_value":"0807.0247v1","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0807.0247","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"pith_short_12","alias_value":"VMUVYFXHZDGZ","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_16","alias_value":"VMUVYFXHZDGZXLWU","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_8","alias_value":"VMUVYFXH","created_at":"2026-05-18T12:25:58Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2008:VMUVYFXHZDGZXLWU5WEYWDLO2V","target":"record","payload":{"canonical_record":{"source":{"id":"0807.0247","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2008-07-01T22:01:21Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"58ea2c9360b8068236cff920fada9397f786a6cdfc5fd5eeee8ba39eb4a6daef","abstract_canon_sha256":"b93fb8cf527959983d537b229f92405f1af7f5981921aab730ff161213dee1fd"},"schema_version":"1.0"},"canonical_sha256":"ab295c16e7c8cd9baed4ed898b0d6ed5680090c4af92049d049fff3cd981b531","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:29:02.173199Z","signature_b64":"KtkVTdUlJnGZduagS+oaiClI2bhsLJGhZgdASiJn+LvLLjpYlXqgXeFPM7GRL+KBqBJiWKBII7Fc6p1bQhnvCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ab295c16e7c8cd9baed4ed898b0d6ed5680090c4af92049d049fff3cd981b531","last_reissued_at":"2026-05-18T00:29:02.172660Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:29:02.172660Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0807.0247","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:29:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pRfZqIO0ndybMFRL59PgahPvImvDKL04Hw4y9dg9yBhdqT+DIA5VelJhAIXY4oEmg93Fw/UVAiVfunhanX62AA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T20:31:18.701648Z"},"content_sha256":"4ebe4f3a0db709aa3bedd5ea147f98335297785b980282d5b965633a03fb3f6c","schema_version":"1.0","event_id":"sha256:4ebe4f3a0db709aa3bedd5ea147f98335297785b980282d5b965633a03fb3f6c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2008:VMUVYFXHZDGZXLWU5WEYWDLO2V","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Agent-Based Modeling of Host-Pathogen Systems: The Successes and Challenges","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.CB","authors_text":"Alan S. Perelson, Amy L. Bauer, Catherine A.A. Beauchemin","submitted_at":"2008-07-01T22:01:21Z","abstract_excerpt":"Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological processes. We then point out some limitations and challenges of agent-based models and encourage efforts towards reproducibility and model validation."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0807.0247","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:29:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+MAF7KyR0UM4UBuf6CH3kOKntL79aNdBA9bLGQJXDc6XYweBeyDWrnD/0uZYf+TDLiZLzmnryYnuQzAG8XO+CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T20:31:18.701990Z"},"content_sha256":"6866921a8240029d32bf28be48c83dd068823a1266df406b4fe6bdf109b15b9c","schema_version":"1.0","event_id":"sha256:6866921a8240029d32bf28be48c83dd068823a1266df406b4fe6bdf109b15b9c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/bundle.json","state_url":"https://pith.science/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T20:31:18Z","links":{"resolver":"https://pith.science/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V","bundle":"https://pith.science/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/bundle.json","state":"https://pith.science/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VMUVYFXHZDGZXLWU5WEYWDLO2V/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2008:VMUVYFXHZDGZXLWU5WEYWDLO2V","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b93fb8cf527959983d537b229f92405f1af7f5981921aab730ff161213dee1fd","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2008-07-01T22:01:21Z","title_canon_sha256":"58ea2c9360b8068236cff920fada9397f786a6cdfc5fd5eeee8ba39eb4a6daef"},"schema_version":"1.0","source":{"id":"0807.0247","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0807.0247","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"arxiv_version","alias_value":"0807.0247v1","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0807.0247","created_at":"2026-05-18T00:29:02Z"},{"alias_kind":"pith_short_12","alias_value":"VMUVYFXHZDGZ","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_16","alias_value":"VMUVYFXHZDGZXLWU","created_at":"2026-05-18T12:25:58Z"},{"alias_kind":"pith_short_8","alias_value":"VMUVYFXH","created_at":"2026-05-18T12:25:58Z"}],"graph_snapshots":[{"event_id":"sha256:6866921a8240029d32bf28be48c83dd068823a1266df406b4fe6bdf109b15b9c","target":"graph","created_at":"2026-05-18T00:29:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological processes. We then point out some limitations and challenges of agent-based models and encourage efforts towards reproducibility and model validation.","authors_text":"Alan S. Perelson, Amy L. Bauer, Catherine A.A. Beauchemin","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2008-07-01T22:01:21Z","title":"Agent-Based Modeling of Host-Pathogen Systems: The Successes and Challenges"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0807.0247","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4ebe4f3a0db709aa3bedd5ea147f98335297785b980282d5b965633a03fb3f6c","target":"record","created_at":"2026-05-18T00:29:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b93fb8cf527959983d537b229f92405f1af7f5981921aab730ff161213dee1fd","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2008-07-01T22:01:21Z","title_canon_sha256":"58ea2c9360b8068236cff920fada9397f786a6cdfc5fd5eeee8ba39eb4a6daef"},"schema_version":"1.0","source":{"id":"0807.0247","kind":"arxiv","version":1}},"canonical_sha256":"ab295c16e7c8cd9baed4ed898b0d6ed5680090c4af92049d049fff3cd981b531","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ab295c16e7c8cd9baed4ed898b0d6ed5680090c4af92049d049fff3cd981b531","first_computed_at":"2026-05-18T00:29:02.172660Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:29:02.172660Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"KtkVTdUlJnGZduagS+oaiClI2bhsLJGhZgdASiJn+LvLLjpYlXqgXeFPM7GRL+KBqBJiWKBII7Fc6p1bQhnvCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:29:02.173199Z","signed_message":"canonical_sha256_bytes"},"source_id":"0807.0247","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4ebe4f3a0db709aa3bedd5ea147f98335297785b980282d5b965633a03fb3f6c","sha256:6866921a8240029d32bf28be48c83dd068823a1266df406b4fe6bdf109b15b9c"],"state_sha256":"93e28f6df7873bde7315bf6be2471aa90dc71c8f52e42c889a94c591736c0762"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NIsJRPV1DBfOM0FkUzPqsOFlVTOwJ1Xrny3t79NeeAUUF++0IxdNvak0LYmdA6Jm0gSlOr4dHPC9f17e2MOZBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T20:31:18.703872Z","bundle_sha256":"5e0826eade077cef7c862228f4aa7bd9b3f74e3670edfb7bd2cde070c9bc3609"}}