{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:VY7ROLFKH3J55RXEWGAKY7VY7P","short_pith_number":"pith:VY7ROLFK","canonical_record":{"source":{"id":"1406.2573","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-06-10T14:55:19Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"cff4a409a628c96f8f416ab91adce75d153578ae9a3223a76752212c6c050dee","abstract_canon_sha256":"0d87d39d4f13ef205fd39a7bc0c7dcc2ba283e9db3ad051d6856b61056fcccdf"},"schema_version":"1.0"},"canonical_sha256":"ae3f172caa3ed3dec6e4b180ac7eb8fbf6213dcfb2c5ccc83f25ea32f92ecaab","source":{"kind":"arxiv","id":"1406.2573","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1406.2573","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"arxiv_version","alias_value":"1406.2573v1","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1406.2573","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"pith_short_12","alias_value":"VY7ROLFKH3J5","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"VY7ROLFKH3J55RXE","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"VY7ROLFK","created_at":"2026-05-18T12:28:54Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:VY7ROLFKH3J55RXEWGAKY7VY7P","target":"record","payload":{"canonical_record":{"source":{"id":"1406.2573","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-06-10T14:55:19Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"cff4a409a628c96f8f416ab91adce75d153578ae9a3223a76752212c6c050dee","abstract_canon_sha256":"0d87d39d4f13ef205fd39a7bc0c7dcc2ba283e9db3ad051d6856b61056fcccdf"},"schema_version":"1.0"},"canonical_sha256":"ae3f172caa3ed3dec6e4b180ac7eb8fbf6213dcfb2c5ccc83f25ea32f92ecaab","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:50:01.394230Z","signature_b64":"iuowb6Nv6yYJfCoHauPnItTQsK7ExCWF4JxzaHZ3715hAx6m4J5FzgP3XVUVoCf6VfISAroE2rzm/YUmMdegBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ae3f172caa3ed3dec6e4b180ac7eb8fbf6213dcfb2c5ccc83f25ea32f92ecaab","last_reissued_at":"2026-05-18T02:50:01.393768Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:50:01.393768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1406.2573","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:50:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sk9vXqHz+Hb/qTqwGewPe309/mHs+2UvwewSsKL/l3qYT+U2VnR1I1SSmOv0Wom83kmrpgy4tZG5aW8JV7CLBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T16:04:37.298462Z"},"content_sha256":"cb1f8b348e56a1cb20e6929656517dd5e391c3487b46017a37621135bf202b81","schema_version":"1.0","event_id":"sha256:cb1f8b348e56a1cb20e6929656517dd5e391c3487b46017a37621135bf202b81"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:VY7ROLFKH3J55RXEWGAKY7VY7P","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Image-based Parameter Inference for Spatio-temporal models of Organogenesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Britta Velten, Dagmar Iber, Erkan Uenal","submitted_at":"2014-06-10T14:55:19Z","abstract_excerpt":"Advances in imaging technology now provide us with detailed 3D data on gene expression patterns in developing embryos. This information can be used to build predictive mathematical models of embryogenesis. Current modelling approaches are, however, limited by lack of methods to automatically infer the regulatory networks and the parameter values from the image-based information. Here we make a first step to the development of such methods. We use limb bud development as a model system. For a given regulatory network we developed a decision tree based algorithm to automatically determine parame"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1406.2573","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:50:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"orwXWfJvM/oHahhqfEEAN+WhEG+fbOXlnmUnE3cxyqQIC3N5lW4xA4x/P5hq5I2rl8g+L/P/upQaLi0RvQY6DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T16:04:37.298806Z"},"content_sha256":"abf7a384262c59b079d2336783c484074b799af49a4a63a31d5b44a97e5cfacf","schema_version":"1.0","event_id":"sha256:abf7a384262c59b079d2336783c484074b799af49a4a63a31d5b44a97e5cfacf"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/bundle.json","state_url":"https://pith.science/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T16:04:37Z","links":{"resolver":"https://pith.science/pith/VY7ROLFKH3J55RXEWGAKY7VY7P","bundle":"https://pith.science/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/bundle.json","state":"https://pith.science/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/state.json","well_known_bundle":"https://pith.science/.well-known/pith/VY7ROLFKH3J55RXEWGAKY7VY7P/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:VY7ROLFKH3J55RXEWGAKY7VY7P","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0d87d39d4f13ef205fd39a7bc0c7dcc2ba283e9db3ad051d6856b61056fcccdf","cross_cats_sorted":["q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-06-10T14:55:19Z","title_canon_sha256":"cff4a409a628c96f8f416ab91adce75d153578ae9a3223a76752212c6c050dee"},"schema_version":"1.0","source":{"id":"1406.2573","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1406.2573","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"arxiv_version","alias_value":"1406.2573v1","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1406.2573","created_at":"2026-05-18T02:50:01Z"},{"alias_kind":"pith_short_12","alias_value":"VY7ROLFKH3J5","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_16","alias_value":"VY7ROLFKH3J55RXE","created_at":"2026-05-18T12:28:54Z"},{"alias_kind":"pith_short_8","alias_value":"VY7ROLFK","created_at":"2026-05-18T12:28:54Z"}],"graph_snapshots":[{"event_id":"sha256:abf7a384262c59b079d2336783c484074b799af49a4a63a31d5b44a97e5cfacf","target":"graph","created_at":"2026-05-18T02:50:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Advances in imaging technology now provide us with detailed 3D data on gene expression patterns in developing embryos. This information can be used to build predictive mathematical models of embryogenesis. Current modelling approaches are, however, limited by lack of methods to automatically infer the regulatory networks and the parameter values from the image-based information. Here we make a first step to the development of such methods. We use limb bud development as a model system. For a given regulatory network we developed a decision tree based algorithm to automatically determine parame","authors_text":"Britta Velten, Dagmar Iber, Erkan Uenal","cross_cats":["q-bio.TO"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-06-10T14:55:19Z","title":"Image-based Parameter Inference for Spatio-temporal models of Organogenesis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1406.2573","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cb1f8b348e56a1cb20e6929656517dd5e391c3487b46017a37621135bf202b81","target":"record","created_at":"2026-05-18T02:50:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0d87d39d4f13ef205fd39a7bc0c7dcc2ba283e9db3ad051d6856b61056fcccdf","cross_cats_sorted":["q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-06-10T14:55:19Z","title_canon_sha256":"cff4a409a628c96f8f416ab91adce75d153578ae9a3223a76752212c6c050dee"},"schema_version":"1.0","source":{"id":"1406.2573","kind":"arxiv","version":1}},"canonical_sha256":"ae3f172caa3ed3dec6e4b180ac7eb8fbf6213dcfb2c5ccc83f25ea32f92ecaab","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ae3f172caa3ed3dec6e4b180ac7eb8fbf6213dcfb2c5ccc83f25ea32f92ecaab","first_computed_at":"2026-05-18T02:50:01.393768Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:50:01.393768Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"iuowb6Nv6yYJfCoHauPnItTQsK7ExCWF4JxzaHZ3715hAx6m4J5FzgP3XVUVoCf6VfISAroE2rzm/YUmMdegBg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:50:01.394230Z","signed_message":"canonical_sha256_bytes"},"source_id":"1406.2573","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cb1f8b348e56a1cb20e6929656517dd5e391c3487b46017a37621135bf202b81","sha256:abf7a384262c59b079d2336783c484074b799af49a4a63a31d5b44a97e5cfacf"],"state_sha256":"b87759528c69a21db5e8995f48ca153a900a2d2fdc6fd8b788baa80ba7a3fb4e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FrOu/bACDTOLCk1kUMzmmBH1d61cBMiYx85wryfECZ/qYvXjBdWdAz2K0RNCWwAfxsohswvLZzeBZE3SJjaBAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T16:04:37.300882Z","bundle_sha256":"f4ab5d2e0aee4a0b30d59c4ac79b40a02fa454e29d75578dc3b89166f0ff4555"}}