{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2019:WHJCI5735VWHARZMODIAG3NCRZ","short_pith_number":"pith:WHJCI573","schema_version":"1.0","canonical_sha256":"b1d22477fbed6c70472c70d0036da28e6bcaf8eaa309925e9e2579d1bbb2f9b0","source":{"kind":"arxiv","id":"1902.09345","version":3},"attestation_state":"computed","paper":{"title":"The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Aina Fernandez Rodriguez, Amin Alamshah, Carlo Viscomi, Eleanor Spreckley, Elina Akalestou, Kevin G Murphy, Nick S Jones, Thomas M McGrath","submitted_at":"2019-02-22T11:57:59Z","abstract_excerpt":"Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of PYY 3-36, lithium chloride, GLP-1 and leptin shows the precise behavioural changes caused by each anorectic agent, and demonstrates that these changes do not mimic satiety. In the ad libitum fed state during the light period, meal "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1902.09345","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-02-22T11:57:59Z","cross_cats_sorted":[],"title_canon_sha256":"63ac3a084d0c19ae53038ff02b810a5729f8dc0a33134a29d1fd1a841a67df0d","abstract_canon_sha256":"b21d652d54344dd88846641735ae7021ad0351262fc08fd20c6a52c5eb676612"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:46:41.050259Z","signature_b64":"ILEhhAWYPPji4wdIdtRDJdRRoxbVJi7jAufBxccdbRTxWctxnLvywIKLzsDerF3YNniCMLdUhC7yD/yHBtcWDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b1d22477fbed6c70472c70d0036da28e6bcaf8eaa309925e9e2579d1bbb2f9b0","last_reissued_at":"2026-05-17T23:46:41.049498Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:46:41.049498Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Aina Fernandez Rodriguez, Amin Alamshah, Carlo Viscomi, Eleanor Spreckley, Elina Akalestou, Kevin G Murphy, Nick S Jones, Thomas M McGrath","submitted_at":"2019-02-22T11:57:59Z","abstract_excerpt":"Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of PYY 3-36, lithium chloride, GLP-1 and leptin shows the precise behavioural changes caused by each anorectic agent, and demonstrates that these changes do not mimic satiety. In the ad libitum fed state during the light period, meal "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1902.09345","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1902.09345","created_at":"2026-05-17T23:46:41.049620+00:00"},{"alias_kind":"arxiv_version","alias_value":"1902.09345v3","created_at":"2026-05-17T23:46:41.049620+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1902.09345","created_at":"2026-05-17T23:46:41.049620+00:00"},{"alias_kind":"pith_short_12","alias_value":"WHJCI5735VWH","created_at":"2026-05-18T12:33:30.264802+00:00"},{"alias_kind":"pith_short_16","alias_value":"WHJCI5735VWHARZM","created_at":"2026-05-18T12:33:30.264802+00:00"},{"alias_kind":"pith_short_8","alias_value":"WHJCI573","created_at":"2026-05-18T12:33:30.264802+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ","json":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ.json","graph_json":"https://pith.science/api/pith-number/WHJCI5735VWHARZMODIAG3NCRZ/graph.json","events_json":"https://pith.science/api/pith-number/WHJCI5735VWHARZMODIAG3NCRZ/events.json","paper":"https://pith.science/paper/WHJCI573"},"agent_actions":{"view_html":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ","download_json":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ.json","view_paper":"https://pith.science/paper/WHJCI573","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1902.09345&json=true","fetch_graph":"https://pith.science/api/pith-number/WHJCI5735VWHARZMODIAG3NCRZ/graph.json","fetch_events":"https://pith.science/api/pith-number/WHJCI5735VWHARZMODIAG3NCRZ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ/action/storage_attestation","attest_author":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ/action/author_attestation","sign_citation":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ/action/citation_signature","submit_replication":"https://pith.science/pith/WHJCI5735VWHARZMODIAG3NCRZ/action/replication_record"}},"created_at":"2026-05-17T23:46:41.049620+00:00","updated_at":"2026-05-17T23:46:41.049620+00:00"}