{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:WMM6PPPA43Z63WCGPP3IB64A4W","short_pith_number":"pith:WMM6PPPA","schema_version":"1.0","canonical_sha256":"b319e7bde0e6f3edd8467bf680fb80e5ae8b78741ed62d57c06cd5ef06dc86d9","source":{"kind":"arxiv","id":"1503.00399","version":2},"attestation_state":"computed","paper":{"title":"Robust and probabilistic optimization of dose schedules in radiotherapy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.med-ph"],"primary_cat":"q-bio.TO","authors_text":"Hamidreza Badri, Kevin Leder, Yoichi Watanabe","submitted_at":"2015-03-02T03:10:16Z","abstract_excerpt":"We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to radiation or sparing factor of the OAR are not accounted for during radiation scheduling, the performance of the therapy may be strongly degraded or the OAR may receive a substantially larger dose than the maximum threshold. This paper proposes two radiation scheduling concepts to incorporate inter-patient variability into the scheduling optimization problem. T"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1503.00399","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-03-02T03:10:16Z","cross_cats_sorted":["physics.med-ph"],"title_canon_sha256":"764a2cfafdd74ab6c09a3a94cdb1f9baa0585c567d0afd85eb46b005caaf4ffc","abstract_canon_sha256":"eeed39f36135dd5cd6e0ab3d8ea5ac25b27912d24b3a1d537e84331d44be03eb"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:57:41.639028Z","signature_b64":"X2m8sUKns0hnl44Jt7uoZ3W4R37kktYX+gzDwyk5d1rjqwguyTrpS6WZlZEzfTfxLL9Do/ITJJCV420EaDPYAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b319e7bde0e6f3edd8467bf680fb80e5ae8b78741ed62d57c06cd5ef06dc86d9","last_reissued_at":"2026-05-18T01:57:41.638435Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:57:41.638435Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Robust and probabilistic optimization of dose schedules in radiotherapy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.med-ph"],"primary_cat":"q-bio.TO","authors_text":"Hamidreza Badri, Kevin Leder, Yoichi Watanabe","submitted_at":"2015-03-02T03:10:16Z","abstract_excerpt":"We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to radiation or sparing factor of the OAR are not accounted for during radiation scheduling, the performance of the therapy may be strongly degraded or the OAR may receive a substantially larger dose than the maximum threshold. This paper proposes two radiation scheduling concepts to incorporate inter-patient variability into the scheduling optimization problem. T"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.00399","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1503.00399","created_at":"2026-05-18T01:57:41.638555+00:00"},{"alias_kind":"arxiv_version","alias_value":"1503.00399v2","created_at":"2026-05-18T01:57:41.638555+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.00399","created_at":"2026-05-18T01:57:41.638555+00:00"},{"alias_kind":"pith_short_12","alias_value":"WMM6PPPA43Z6","created_at":"2026-05-18T12:29:47.479230+00:00"},{"alias_kind":"pith_short_16","alias_value":"WMM6PPPA43Z63WCG","created_at":"2026-05-18T12:29:47.479230+00:00"},{"alias_kind":"pith_short_8","alias_value":"WMM6PPPA","created_at":"2026-05-18T12:29:47.479230+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W","json":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W.json","graph_json":"https://pith.science/api/pith-number/WMM6PPPA43Z63WCGPP3IB64A4W/graph.json","events_json":"https://pith.science/api/pith-number/WMM6PPPA43Z63WCGPP3IB64A4W/events.json","paper":"https://pith.science/paper/WMM6PPPA"},"agent_actions":{"view_html":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W","download_json":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W.json","view_paper":"https://pith.science/paper/WMM6PPPA","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1503.00399&json=true","fetch_graph":"https://pith.science/api/pith-number/WMM6PPPA43Z63WCGPP3IB64A4W/graph.json","fetch_events":"https://pith.science/api/pith-number/WMM6PPPA43Z63WCGPP3IB64A4W/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W/action/timestamp_anchor","attest_storage":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W/action/storage_attestation","attest_author":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W/action/author_attestation","sign_citation":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W/action/citation_signature","submit_replication":"https://pith.science/pith/WMM6PPPA43Z63WCGPP3IB64A4W/action/replication_record"}},"created_at":"2026-05-18T01:57:41.638555+00:00","updated_at":"2026-05-18T01:57:41.638555+00:00"}