{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:WSU7TY2WYKQ2CXTXL5TLOEUYDZ","short_pith_number":"pith:WSU7TY2W","schema_version":"1.0","canonical_sha256":"b4a9f9e356c2a1a15e775f66b712981e6714e1b50eb6e319b0f55650e90cb570","source":{"kind":"arxiv","id":"1701.07504","version":1},"attestation_state":"computed","paper":{"title":"Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"A. Picciotto, D Margarone, F. Perozziello, F. Romano, GAP Cirrone, G. Cuttone, G. Korn, G. Milluzzo, G. Petringa, L Giuffrida, L Manti, V. Marchese, V. Scuderi","submitted_at":"2017-01-25T22:05:20Z","abstract_excerpt":"Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) $^{12}$C ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper $^{12}$C-ion clinical amenability. Thus, e"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1701.07504","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2017-01-25T22:05:20Z","cross_cats_sorted":[],"title_canon_sha256":"0dc55bf66aa63dd84d32622b870eadcb9fbf02646e26dbe1ec815e3afc098e13","abstract_canon_sha256":"ff8bbefcdc4b4aa88bda939a8a5c33eaa767c0655636c938363ced357b91d736"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:52:03.292805Z","signature_b64":"BSuW0K+lIkPX48dkxsU3BuzVu5QX5e1YaxG2h+flRkPEXHKW41g3uTPgltNYH6XdAAmTvTduvd67Yl23wom6AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b4a9f9e356c2a1a15e775f66b712981e6714e1b50eb6e319b0f55650e90cb570","last_reissued_at":"2026-05-18T00:52:03.292349Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:52:03.292349Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"A. Picciotto, D Margarone, F. Perozziello, F. Romano, GAP Cirrone, G. Cuttone, G. Korn, G. Milluzzo, G. Petringa, L Giuffrida, L Manti, V. Marchese, V. Scuderi","submitted_at":"2017-01-25T22:05:20Z","abstract_excerpt":"Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) $^{12}$C ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper $^{12}$C-ion clinical amenability. Thus, e"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.07504","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1701.07504","created_at":"2026-05-18T00:52:03.292423+00:00"},{"alias_kind":"arxiv_version","alias_value":"1701.07504v1","created_at":"2026-05-18T00:52:03.292423+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.07504","created_at":"2026-05-18T00:52:03.292423+00:00"},{"alias_kind":"pith_short_12","alias_value":"WSU7TY2WYKQ2","created_at":"2026-05-18T12:31:53.515858+00:00"},{"alias_kind":"pith_short_16","alias_value":"WSU7TY2WYKQ2CXTX","created_at":"2026-05-18T12:31:53.515858+00:00"},{"alias_kind":"pith_short_8","alias_value":"WSU7TY2W","created_at":"2026-05-18T12:31:53.515858+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ","json":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ.json","graph_json":"https://pith.science/api/pith-number/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/graph.json","events_json":"https://pith.science/api/pith-number/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/events.json","paper":"https://pith.science/paper/WSU7TY2W"},"agent_actions":{"view_html":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ","download_json":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ.json","view_paper":"https://pith.science/paper/WSU7TY2W","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1701.07504&json=true","fetch_graph":"https://pith.science/api/pith-number/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/graph.json","fetch_events":"https://pith.science/api/pith-number/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/action/storage_attestation","attest_author":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/action/author_attestation","sign_citation":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/action/citation_signature","submit_replication":"https://pith.science/pith/WSU7TY2WYKQ2CXTXL5TLOEUYDZ/action/replication_record"}},"created_at":"2026-05-18T00:52:03.292423+00:00","updated_at":"2026-05-18T00:52:03.292423+00:00"}