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In this paper, a connection between the gamma-ray and optical variability of 3C345 and properties of its parsec-scale radio emission is investigated. Methods: The Fermi-LAT data of 3C345, covering an energy range of 0.1-300 GeV, were combined with 32 Very Long Baseline Array observations of the object made at 43.2 GHz in the period of January 2008 - March 2010. 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