{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:XAAAGYQF53MG3JWKO5KV45CTPJ","short_pith_number":"pith:XAAAGYQF","canonical_record":{"source":{"id":"2105.08288","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2021-05-18T05:32:07Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"01c9c8077e63801c60b3773ba516f71391609b7d4506f55dab0842d7559cbe09","abstract_canon_sha256":"702a8bf42942ab037cd6393e7117972e006c033c6fbc3c011f72f699c0889df2"},"schema_version":"1.0"},"canonical_sha256":"b800036205eed86da6ca77555e74537a5c0805ebd64b35f067874e643c642956","source":{"kind":"arxiv","id":"2105.08288","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2105.08288","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"arxiv_version","alias_value":"2105.08288v4","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2105.08288","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_12","alias_value":"XAAAGYQF53MG","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_16","alias_value":"XAAAGYQF53MG3JWK","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_8","alias_value":"XAAAGYQF","created_at":"2026-07-05T03:21:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:XAAAGYQF53MG3JWKO5KV45CTPJ","target":"record","payload":{"canonical_record":{"source":{"id":"2105.08288","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2021-05-18T05:32:07Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"01c9c8077e63801c60b3773ba516f71391609b7d4506f55dab0842d7559cbe09","abstract_canon_sha256":"702a8bf42942ab037cd6393e7117972e006c033c6fbc3c011f72f699c0889df2"},"schema_version":"1.0"},"canonical_sha256":"b800036205eed86da6ca77555e74537a5c0805ebd64b35f067874e643c642956","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:21:11.070688Z","signature_b64":"AbmFgWPM8sTdiy2FEBm+FBiHSL4RkR0vxZr9snedtQXRGPQAW6mMXjuPAFr6rgAfPBCgUhLH01fe+Yr5h1zJAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"b800036205eed86da6ca77555e74537a5c0805ebd64b35f067874e643c642956","last_reissued_at":"2026-07-05T03:21:11.070256Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:21:11.070256Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2105.08288","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:21:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wG1jc0EA6ZhUe6/Mm45w84hQLGlDPBbePcorMlgS8dwrJuVwPsHdqjDt0Dn+I2gFQaN/H4xc1RWy5CaQNw8/DA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T10:53:55.037289Z"},"content_sha256":"1b2213d4122f1904a0dc46a399a2eceb6232c754f4791fc3084e92b4ae25e6fe","schema_version":"1.0","event_id":"sha256:1b2213d4122f1904a0dc46a399a2eceb6232c754f4791fc3084e92b4ae25e6fe"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:XAAAGYQF53MG3JWKO5KV45CTPJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Kuramoto model based analysis reveals oxytocin effects on brain network dynamics","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.NC","authors_text":"Haiyan Wu, Qingyuan Wu, Quanying Liu, Shuhan Zheng, Youzhi Qu, Zhichao Liang","submitted_at":"2021-05-18T05:32:07Z","abstract_excerpt":"The oxytocin effects on large-scale brain networks such as Default Mode Network (DMN) and Frontoparietal Network (FPN) have been largely studied using fMRI data. However, these studies are mainly based on the statistical correlation or Bayesian causality inference, lacking interpretability at physical and neuroscience level. Here, we propose a physics-based framework of Kuramoto model to investigate oxytocin effects on the phase dynamic neural coupling in DMN and FPN. Testing on fMRI data of 59 participants administrated with either oxytocin or placebo, we demonstrate that oxytocin changes the"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2105.08288","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2105.08288/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:21:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mSP8XdLYN4wC/PiXO6Kd6QR8TnxtFI/XoYELMRsNbOywNgG6MqH4lmxWzTM743VaMb7pJqjSdmqhZTR+gETXAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T10:53:55.037680Z"},"content_sha256":"908fdef5ce8ad8e28a113ad695b31b1327429d07bf11637e2273370f5d44501c","schema_version":"1.0","event_id":"sha256:908fdef5ce8ad8e28a113ad695b31b1327429d07bf11637e2273370f5d44501c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/bundle.json","state_url":"https://pith.science/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-23T10:53:55Z","links":{"resolver":"https://pith.science/pith/XAAAGYQF53MG3JWKO5KV45CTPJ","bundle":"https://pith.science/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/bundle.json","state":"https://pith.science/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/XAAAGYQF53MG3JWKO5KV45CTPJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:XAAAGYQF53MG3JWKO5KV45CTPJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"702a8bf42942ab037cd6393e7117972e006c033c6fbc3c011f72f699c0889df2","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2021-05-18T05:32:07Z","title_canon_sha256":"01c9c8077e63801c60b3773ba516f71391609b7d4506f55dab0842d7559cbe09"},"schema_version":"1.0","source":{"id":"2105.08288","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2105.08288","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"arxiv_version","alias_value":"2105.08288v4","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2105.08288","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_12","alias_value":"XAAAGYQF53MG","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_16","alias_value":"XAAAGYQF53MG3JWK","created_at":"2026-07-05T03:21:11Z"},{"alias_kind":"pith_short_8","alias_value":"XAAAGYQF","created_at":"2026-07-05T03:21:11Z"}],"graph_snapshots":[{"event_id":"sha256:908fdef5ce8ad8e28a113ad695b31b1327429d07bf11637e2273370f5d44501c","target":"graph","created_at":"2026-07-05T03:21:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2105.08288/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The oxytocin effects on large-scale brain networks such as Default Mode Network (DMN) and Frontoparietal Network (FPN) have been largely studied using fMRI data. However, these studies are mainly based on the statistical correlation or Bayesian causality inference, lacking interpretability at physical and neuroscience level. Here, we propose a physics-based framework of Kuramoto model to investigate oxytocin effects on the phase dynamic neural coupling in DMN and FPN. Testing on fMRI data of 59 participants administrated with either oxytocin or placebo, we demonstrate that oxytocin changes the","authors_text":"Haiyan Wu, Qingyuan Wu, Quanying Liu, Shuhan Zheng, Youzhi Qu, Zhichao Liang","cross_cats":["q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2021-05-18T05:32:07Z","title":"Kuramoto model based analysis reveals oxytocin effects on brain network dynamics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2105.08288","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1b2213d4122f1904a0dc46a399a2eceb6232c754f4791fc3084e92b4ae25e6fe","target":"record","created_at":"2026-07-05T03:21:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"702a8bf42942ab037cd6393e7117972e006c033c6fbc3c011f72f699c0889df2","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.NC","submitted_at":"2021-05-18T05:32:07Z","title_canon_sha256":"01c9c8077e63801c60b3773ba516f71391609b7d4506f55dab0842d7559cbe09"},"schema_version":"1.0","source":{"id":"2105.08288","kind":"arxiv","version":4}},"canonical_sha256":"b800036205eed86da6ca77555e74537a5c0805ebd64b35f067874e643c642956","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"b800036205eed86da6ca77555e74537a5c0805ebd64b35f067874e643c642956","first_computed_at":"2026-07-05T03:21:11.070256Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:21:11.070256Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"AbmFgWPM8sTdiy2FEBm+FBiHSL4RkR0vxZr9snedtQXRGPQAW6mMXjuPAFr6rgAfPBCgUhLH01fe+Yr5h1zJAA==","signature_status":"signed_v1","signed_at":"2026-07-05T03:21:11.070688Z","signed_message":"canonical_sha256_bytes"},"source_id":"2105.08288","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1b2213d4122f1904a0dc46a399a2eceb6232c754f4791fc3084e92b4ae25e6fe","sha256:908fdef5ce8ad8e28a113ad695b31b1327429d07bf11637e2273370f5d44501c"],"state_sha256":"67562e0cfd1b3b087d8f1b0e327b1fc5294e176d7ae8fa90d3b85b1113a4715c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HX3FGKF1Zf2UJsPZGrYSKFvUfKd2kjG+9DdjSfCfHDG9lOeXJ8LjIOYaypGF7AS+CGFA+gdbxc71T+WKetIXBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-23T10:53:55.040147Z","bundle_sha256":"742c64ce6942edab2a6cb43081353ca582c944874fbaa8b50e81cb0b22628d46"}}