{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:YLPOZ6PRRXKBQBMZ6RCUMCI7KF","short_pith_number":"pith:YLPOZ6PR","canonical_record":{"source":{"id":"1803.02585","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-07T10:34:40Z","cross_cats_sorted":["cond-mat.dis-nn","q-bio.SC"],"title_canon_sha256":"900d9bc15a5fee1895af2635a56163478a2dfbcb72fd417321348115364411c2","abstract_canon_sha256":"396ccdf4bb6530ad1aeeb07fdc9d4c49695caf53ae7a64d683cd08079564aa2a"},"schema_version":"1.0"},"canonical_sha256":"c2deecf9f18dd4180599f44546091f51430cadd1fcd6e5ee84b5149d99952e5b","source":{"kind":"arxiv","id":"1803.02585","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1803.02585","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"arxiv_version","alias_value":"1803.02585v1","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.02585","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"pith_short_12","alias_value":"YLPOZ6PRRXKB","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_16","alias_value":"YLPOZ6PRRXKBQBMZ","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_8","alias_value":"YLPOZ6PR","created_at":"2026-05-18T12:33:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:YLPOZ6PRRXKBQBMZ6RCUMCI7KF","target":"record","payload":{"canonical_record":{"source":{"id":"1803.02585","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-07T10:34:40Z","cross_cats_sorted":["cond-mat.dis-nn","q-bio.SC"],"title_canon_sha256":"900d9bc15a5fee1895af2635a56163478a2dfbcb72fd417321348115364411c2","abstract_canon_sha256":"396ccdf4bb6530ad1aeeb07fdc9d4c49695caf53ae7a64d683cd08079564aa2a"},"schema_version":"1.0"},"canonical_sha256":"c2deecf9f18dd4180599f44546091f51430cadd1fcd6e5ee84b5149d99952e5b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:21:49.762493Z","signature_b64":"85n7T56B4Mcu0OGOgvY2YHj/vWSZpuvbSMBXdsKk564VrQTvnaDmZ5m/+rzWiIiQJi2OwTCRtZCFPuEixFaHAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c2deecf9f18dd4180599f44546091f51430cadd1fcd6e5ee84b5149d99952e5b","last_reissued_at":"2026-05-18T00:21:49.761973Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:21:49.761973Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1803.02585","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:21:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"V6HWrRq6SI0Icu+OhjTQXI+qCFXiTfVxoYBGGEWQECSsYYMMcMK3zoSBxvlVVbDGWzCdIn39ULQB8LqQYooUDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-25T17:44:53.909833Z"},"content_sha256":"232e16b44f9523e941b195571113f769e85d4ef5759617c14a3653e3d50c8aa2","schema_version":"1.0","event_id":"sha256:232e16b44f9523e941b195571113f769e85d4ef5759617c14a3653e3d50c8aa2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:YLPOZ6PRRXKBQBMZ6RCUMCI7KF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Single-molecular and Ensemble-level Oscillations of Cyanobacterial Circadian Clock","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cond-mat.dis-nn","q-bio.SC"],"primary_cat":"q-bio.MN","authors_text":"Masaki Sasai, Sumita Das, Tomoki P. Terada","submitted_at":"2018-03-07T10:34:40Z","abstract_excerpt":"When three cyanobacterial proteins, KaiA, KaiB, and KaiC, are incubated with ATP in vitro, the phosphorylation level of KaiC hexamers shows stable oscillation with approximately 24 h period. In order to understand this KaiABC clockwork, we need to analyze both the macroscopic synchronization of a large number of KaiC hexamers and the microscopic reactions and structural changes in individual KaiC molecules. In the present paper, we explain two coarse-grained theoretical models, the many-molecule (MM) model and the single-molecule (SM) model, to bridge the gap between macroscopic and microscopi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.02585","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:21:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1/gMQJXaH4vUh1GFDBQ+iDXihzfEUlWtuuKby7CS0a5YxQPx5eo11SzeUWANEAATTBR97mceSDmbaU1GCQWECA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-25T17:44:53.910184Z"},"content_sha256":"b73065998a06e708d9156f50e74fd9e57aa22dec2cdc4ef8bf80bee9f9a9161f","schema_version":"1.0","event_id":"sha256:b73065998a06e708d9156f50e74fd9e57aa22dec2cdc4ef8bf80bee9f9a9161f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/bundle.json","state_url":"https://pith.science/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-25T17:44:53Z","links":{"resolver":"https://pith.science/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF","bundle":"https://pith.science/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/bundle.json","state":"https://pith.science/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/YLPOZ6PRRXKBQBMZ6RCUMCI7KF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:YLPOZ6PRRXKBQBMZ6RCUMCI7KF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"396ccdf4bb6530ad1aeeb07fdc9d4c49695caf53ae7a64d683cd08079564aa2a","cross_cats_sorted":["cond-mat.dis-nn","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-07T10:34:40Z","title_canon_sha256":"900d9bc15a5fee1895af2635a56163478a2dfbcb72fd417321348115364411c2"},"schema_version":"1.0","source":{"id":"1803.02585","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1803.02585","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"arxiv_version","alias_value":"1803.02585v1","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.02585","created_at":"2026-05-18T00:21:49Z"},{"alias_kind":"pith_short_12","alias_value":"YLPOZ6PRRXKB","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_16","alias_value":"YLPOZ6PRRXKBQBMZ","created_at":"2026-05-18T12:33:04Z"},{"alias_kind":"pith_short_8","alias_value":"YLPOZ6PR","created_at":"2026-05-18T12:33:04Z"}],"graph_snapshots":[{"event_id":"sha256:b73065998a06e708d9156f50e74fd9e57aa22dec2cdc4ef8bf80bee9f9a9161f","target":"graph","created_at":"2026-05-18T00:21:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"When three cyanobacterial proteins, KaiA, KaiB, and KaiC, are incubated with ATP in vitro, the phosphorylation level of KaiC hexamers shows stable oscillation with approximately 24 h period. In order to understand this KaiABC clockwork, we need to analyze both the macroscopic synchronization of a large number of KaiC hexamers and the microscopic reactions and structural changes in individual KaiC molecules. In the present paper, we explain two coarse-grained theoretical models, the many-molecule (MM) model and the single-molecule (SM) model, to bridge the gap between macroscopic and microscopi","authors_text":"Masaki Sasai, Sumita Das, Tomoki P. Terada","cross_cats":["cond-mat.dis-nn","q-bio.SC"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-07T10:34:40Z","title":"Single-molecular and Ensemble-level Oscillations of Cyanobacterial Circadian Clock"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.02585","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:232e16b44f9523e941b195571113f769e85d4ef5759617c14a3653e3d50c8aa2","target":"record","created_at":"2026-05-18T00:21:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"396ccdf4bb6530ad1aeeb07fdc9d4c49695caf53ae7a64d683cd08079564aa2a","cross_cats_sorted":["cond-mat.dis-nn","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-07T10:34:40Z","title_canon_sha256":"900d9bc15a5fee1895af2635a56163478a2dfbcb72fd417321348115364411c2"},"schema_version":"1.0","source":{"id":"1803.02585","kind":"arxiv","version":1}},"canonical_sha256":"c2deecf9f18dd4180599f44546091f51430cadd1fcd6e5ee84b5149d99952e5b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c2deecf9f18dd4180599f44546091f51430cadd1fcd6e5ee84b5149d99952e5b","first_computed_at":"2026-05-18T00:21:49.761973Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:21:49.761973Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"85n7T56B4Mcu0OGOgvY2YHj/vWSZpuvbSMBXdsKk564VrQTvnaDmZ5m/+rzWiIiQJi2OwTCRtZCFPuEixFaHAg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:21:49.762493Z","signed_message":"canonical_sha256_bytes"},"source_id":"1803.02585","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:232e16b44f9523e941b195571113f769e85d4ef5759617c14a3653e3d50c8aa2","sha256:b73065998a06e708d9156f50e74fd9e57aa22dec2cdc4ef8bf80bee9f9a9161f"],"state_sha256":"f14bd5da0ced5734833c8729269a0ac2a0475b98cc2a38175562f267e37f9cb0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iTEONNYkFBRxZtiTKly4xMPLzS8iWT25LpCeN/8KvpVOKyhFPYpenoefnYchLD70gFSkTDoL78k9p9F1jNqRDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-25T17:44:53.912240Z","bundle_sha256":"dd3eb5ca5bc79129e45865bc97e62a5a72749ee5e0feb7b5f668dd311788f65f"}}