A parameter-efficient adapter that injects drug embeddings into a frozen single-cell transformer achieves state-of-the-art perturbation response prediction, including zero-shot generalization to new cell lines.
The art and practice of structure-based drug design: a molecular modeling perspective
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Efficient Fine-Tuning of Single-Cell Foundation Models Enables Zero-Shot Molecular Perturbation Prediction
A parameter-efficient adapter that injects drug embeddings into a frozen single-cell transformer achieves state-of-the-art perturbation response prediction, including zero-shot generalization to new cell lines.