TrajOnco uses a chain-of-agents LLM architecture with memory to perform temporal reasoning on longitudinal EHR, achieving 0.64-0.80 AUROC for 1-year multi-cancer risk prediction in zero-shot mode on matched cohorts while matching supervised ML on lung cancer and outperforming single-agent baselines.
InProceedings of the 27th International Conference on Computational Linguistics, pages 3402–3413, Santa Fe, New Mexico, USA
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TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection
TrajOnco uses a chain-of-agents LLM architecture with memory to perform temporal reasoning on longitudinal EHR, achieving 0.64-0.80 AUROC for 1-year multi-cancer risk prediction in zero-shot mode on matched cohorts while matching supervised ML on lung cancer and outperforming single-agent baselines.
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