Paper Citation Record · LEDGER

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis

As of 19 August 2026, this Paper Citation Record lists 32 of 32 outbound references and 0 inbound Pith citation observations for arXiv:2608.07865.

A citation records a reference. It does not transfer a finding from one paper to another.

pith.paper-citation-record.v1
2608.07865 v1

Coverage vector

measured 32 of 32 reference resolution

Typed states for the displayed outbound observations.

Source: paper_references, paper_reference_links, observed 2026-08-12T00:51:28.965076Z

measured 32 of 32 standing notices

One-hop event checks from named stored sources.

Source: scholarly_work_events, retraction_status_cache, observed 2026-08-18T06:34:40.430872+00:00

measured 0 of 0 inbound itemization

Pith citing papers itemized under the disclosed page cap.

Source: paper_references, paper_reference_links

measured 0 of 1 external citation measurements

A source-named dated measurement, never combined with another source.

Source: cited_works

Reference resolution

32 of 32 outbound references displayed

verified exact18
verified fuzzy2
unresolved7
parse uncertain0
malformed identifier3
metadata mismatch2

External citation measurements

No source-named external measurement is stored.

Outbound references

Observation 967efa79-02a6-467d-8910-b879e68763fd · outbound

This paper cites Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Reference 1

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.867904Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation eaac5d5a-67fe-4d82-8127-f0e58277c5f3 · outbound

This paper cites Traylor, Mark N.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Traylor, Mark N

Reference 2

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.200625Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 254d15a4-0db2-4400-a1ea-afa06f0eb1ac · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 3

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.191210Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 77b9c3a1-551a-47a8-9276-59046e1a41d6 · outbound

This paper cites Dailey and Amy E.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Dailey and Amy E

Reference 4

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.182286Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 1e30980a-0254-46dd-af7d-fe790801051c · outbound

This paper cites Dailey, and Amy E.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Dailey, and Amy E

Reference 5

Resolution: metadata mismatch; raw_fallback, observed 2026-08-12T00:51:29.464766Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation b01068c3-1ee3-4bfb-90dd-51724cf343d6 · outbound

This paper cites MEK reduces cancer-specific PpIX accumulation through the RSK- ABCB1 and HIF-1α-FECH axes.Scientific Reports, 10(1):22124, December 2020.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis MEK reduces cancer-specific PpIX accumulation through the RSK- ABCB1 and HIF-1α-FECH axes.Scientific Reports, 10(1):22124, December 2020

Reference 6

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.172999Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation aa04487f-58ff-4d80-aeb7-cac758743eb8 · outbound

This paper cites A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.International Journal of Molecular Sciences, 23(14):7974, July 2022.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.International Journal of Molecular Sciences, 23(14):7974, July 2022

Reference 7

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.162134Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 579d7ff3-3de7-4c81-b7c7-4cea076d1d86 · outbound

This paper cites Schulz, Anika M.S.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Schulz, Anika M.S

Reference 8

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.152595Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 16327cea-8215-4c5a-a234-a3bcd1918040 · outbound

This paper cites Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas

Reference 9

Resolution: metadata mismatch; raw_fallback, observed 2026-08-12T00:51:29.389268Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 224c5f9f-c09c-47d1-9160-6f54de3eb94e · outbound

This paper cites Almiron Bonnin et al.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Almiron Bonnin et al

Reference 10

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.142756Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation e49daf28-37f9-40c4-bd06-cdde8e54f31d · outbound

This paper cites Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.Molecular Neurobiology, 54(7):5699–5708, September 2017.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.Molecular Neurobiology, 54(7):5699–5708, September 2017

Reference 11

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.133145Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation c33c3c46-83d5-4fb2-ac3a-c26a1a1e69aa · outbound

This paper cites Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway.Theranostics, 8(8):2134–2146, 2018.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway.Theranostics, 8(8):2134–2146, 2018

Reference 12

Resolution: malformed identifier; doi_truncated, observed 2026-08-12T00:51:29.124553Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 49b20a48-67fc-438e-9895-2077b6627515 · outbound

This paper cites Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature, 455(7216):1061–1068, October 2008.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature, 455(7216):1061–1068, October 2008

Reference 13

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.907245Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation 8fd150e2-be06-4a3c-8df1-a20c3da026a5 · outbound

This paper cites It’s all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis It’s all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma

Reference 14

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.108619Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation b1cf4da5-f656-4c49-acdf-fee3943823d9 · outbound

This paper cites Tumor Purity as an Underlying Key Factor in Glioma.Clinical Cancer Re- search, 23(20):6279–6291, October 2017.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Tumor Purity as an Underlying Key Factor in Glioma.Clinical Cancer Re- search, 23(20):6279–6291, October 2017

Reference 15

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.913808Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation 0e94c5fc-3cdd-42ee-b239-5e4d3b9fa3bf · outbound

This paper cites Inferring tumour purity and stromal and immune cell admixture from expression data.Nature Communications, 4(1):2612, October 2013.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Inferring tumour purity and stromal and immune cell admixture from expression data.Nature Communications, 4(1):2612, October 2013

Reference 16

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.093766Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 34e39e18-cc43-44a9-9933-12d9fb5f7b0e · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 17

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.084967Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation eac89bf5-73da-409e-8fc8-6706b05d7eda · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 18

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.076334Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 212321fe-695f-4553-baca-78ab88aed5b5 · outbound

This paper cites A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.npj Precision Oncology, 2(1):7, March 2018.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.npj Precision Oncology, 2(1):7, March 2018

Reference 19

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.066881Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation bc553dd2-9820-481e-84e4-ed082bd29fbc · outbound

This paper cites Barbie et al.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Barbie et al

Reference 20

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.927925Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation 0f198d4f-e97f-434c-b4f4-888b5fe423d8 · outbound

This paper cites Mesirov, and Pablo Tamayo.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Mesirov, and Pablo Tamayo

Reference 21

Resolution: verified fuzzy; raw_fallback, observed 2026-08-12T00:51:29.492670Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 109c5b06-e1b1-4ecf-b1d6-a92245642759 · outbound

This paper cites GSV A: gene set variation analysis for microarray and RNA-Seq data.BMC Bioinformatics, 14(1):7, December 2013.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis GSV A: gene set variation analysis for microarray and RNA-Seq data.BMC Bioinformatics, 14(1):7, December 2013

Reference 22

Resolution: malformed identifier; raw_fallback, observed 2026-08-12T00:51:29.483131Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 6c494c91-454d-4835-82d0-a2db3e95d335 · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 23

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.045718Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 061e7325-898b-41c4-a502-e736a54bca17 · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 24

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.034318Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 5936175e-803a-476e-ba58-08cdb689ee02 · outbound

This paper cites Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Cell, 164(3):550–563, January 2016.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Cell, 164(3):550–563, January 2016

Reference 25

Resolution: malformed identifier; no resolver link, observed 2026-08-12T00:51:28.944774Z

Source-reported events for the cited work

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Observation d49f90b0-18f5-4b62-818d-3cb963bc270e · outbound

This paper cites Goldman et al.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Goldman et al

Reference 26

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.948025Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation c6f94c56-ad96-40d2-b0aa-873ce2223fd2 · outbound

This paper cites ppcor: An R Package for a Fast Calculation to Semi-partial Correlation Coefficients.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis ppcor: An R Package for a Fast Calculation to Semi-partial Correlation Coefficients

Reference 27

Resolution: verified fuzzy; raw_fallback, observed 2026-08-12T00:51:29.473844Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 4b698204-c0b0-4b74-a97a-b6e0f42dfe77 · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 28

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.958761Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation c136caa1-4cbd-4841-aec7-911e2cd93daa · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 29

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.004484Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Observation 0877fe29-7e9f-4d34-945e-3aee33f77fa5 · outbound

This paper cites Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Cancer Cell, 32(1):42–56.e6, July 2017.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Cancer Cell, 32(1):42–56.e6, July 2017

Reference 30

Resolution: verified exact; doi, observed 2026-08-12T00:51:28.995372Z

Source-reported events for the cited work

correction dated 2018-01-08. Source: crossref record 10.1016/j.ccell.2017.12.012->10.1016/j.ccell.2017.06.003:correction, observed 2026-07-11T03:15:41.027858+00:00. This notice travels one citation hop only.

Observation adcc58bc-fc12-4d68-a1ec-a068c6ed2041 · outbound

This paper cites an unresolved cited work.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis Unresolved cited work

Reference 2015

Resolution: unresolved; no resolver link, observed 2026-08-12T00:51:28.933849Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

Observation bc797acd-198d-4f5f-96f0-87961665afda · outbound

This paper cites URL http://www.csam.or.kr/journal/view.html? doi=10.5351/CSAM.2015.22.6.665.

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis URL http://www.csam.or.kr/journal/view.html? doi=10.5351/CSAM.2015.22.6.665

Reference 4757

Resolution: verified exact; doi, observed 2026-08-12T00:51:29.013411Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-18T06:34:40.430872+00:00.

Pith citing papers

No inbound Pith citation observations are available.