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Paper Citation Record · LEDGER

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3

As of 9 August 2026, this Paper Citation Record lists 28 of 28 outbound references and 0 inbound Pith citation observations for arXiv:2505.21873.

A citation records a reference. It does not transfer a finding from one paper to another.

pith.paper-citation-record.v1
2505.21873 v1

Coverage vector

measured 28 of 28 reference resolution

Typed states for the displayed outbound observations.

Source: paper_references, paper_reference_links, observed 2026-08-07T13:25:01.885819Z

measured 28 of 28 standing notices

One-hop event checks from named stored sources.

Source: scholarly_work_events, retraction_status_cache, observed 2026-08-08T06:32:00.761636+00:00

measured 0 of 0 inbound itemization

Pith citing papers itemized under the disclosed page cap.

Source: paper_references, paper_reference_links

measured 0 of 1 external citation measurements

A source-named dated measurement, never combined with another source.

Source: cited_works

Reference resolution

28 of 28 outbound references displayed

  • verified exact0
  • verified fuzzy19
  • unresolved9
  • parse uncertain0
  • malformed identifier0
  • metadata mismatch0

External citation measurements

No source-named external measurement is stored.

Outbound references

Observation c0c0ed42-b8ee-4ee0-a781-f980ecbb4066 · outbound

This paper cites Protein complex prediction with alphafold-multimer.biorxiv, pages 2021–10, 2021.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein complex prediction with alphafold-multimer.biorxiv, pages 2021–10, 2021

Reference 1

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.529349Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:24:59.208860Z digest=sha256:a346bf083311d6033206333b629541522e27ec051459efac9c81a540b8d633d4

Observation 95f0fc0f-e457-441d-b155-2217fdfd7c42 · outbound

This paper cites Accurate structure prediction of biomolecular interactions with alphafold 3.Nature, 630(8016):493–500, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Accurate structure prediction of biomolecular interactions with alphafold 3.Nature, 630(8016):493–500, 2024

Reference 2

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.246432Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.246432Z digest=sha256:e0b6ee9b63fcc10a3150e8ca56ff1733eb56373e2ae5e52024222a6773809e41

Observation 99666bd3-e263-4647-9622-e314321570ae · outbound

This paper cites Technical Report of HelixFold3 for Biomolecular Structure Prediction.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Technical Report of HelixFold3 for Biomolecular Structure Prediction

Reference 3

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.309561Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.309561Z digest=sha256:abfa1ff5279ac1bbbd6ab9f5c67e2aedccc3fb28787da2adc3da2d7a6399fc91

Observation 46378dc0-b613-46db-947a-b9356f6b7cbc · outbound

This paper cites De novo design of high-affinity protein binders with AlphaProteo.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 De novo design of high-affinity protein binders with AlphaProteo

Reference 4

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.418009Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.418009Z digest=sha256:e873148e624c13c74a1161ad016a9d68b0171ec8dae6209a7f1bcf8a128cea97

Observation af263063-16c9-4cae-a6e2-e2ffd1b30a43 · outbound

This paper cites Bindcraft: one-shot design of functional protein binders.bioRxiv, pages 2024–09, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Bindcraft: one-shot design of functional protein binders.bioRxiv, pages 2024–09, 2024

Reference 5

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.383304Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:24:59.504793Z digest=sha256:7b137b098c397073accf2bce37547f686e08fbe852651dd24c11086c200369ac

Observation 2b2dbcc1-f6c8-432c-9652-19eafdc10a9b · outbound

This paper cites De novo design of protein structure and function with rfdiffusion.Nature, 620(7976):1089–1100, 2023.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 De novo design of protein structure and function with rfdiffusion.Nature, 620(7976):1089–1100, 2023

Reference 6

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.565734Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.565734Z digest=sha256:e3df8a86cf2467fbce5d02e68c434a2db5800c91196c0d9e6331dd68a70c5308

Observation a7728198-2b5e-41c2-bb0a-82787529b114 · outbound

This paper cites Atom level enzyme active site scaffolding using rfdiffusion2.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Atom level enzyme active site scaffolding using rfdiffusion2

Reference 7

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.211922Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:24:59.689478Z digest=sha256:3d84e9d92bdf7c7d27ecfeb037d7261edc5d96812e5c75e1f8f0daa4905120d6

Observation a65990d6-ce77-41b0-aaad-498b5e8da35d · outbound

This paper cites Learning inverse folding from millions of predicted structures.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Learning inverse folding from millions of predicted structures

Reference 8

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.786140Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.786140Z digest=sha256:97daf02ae43bbef7a1562125d1a298495e97b66391f811d0d619bb1da91d444c

Observation e377236f-339f-46be-87ad-56cdd4949cdb · outbound

This paper cites Robust deep learning–based protein sequence design using proteinmpnn.Science, 378(6615):49–56, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Robust deep learning–based protein sequence design using proteinmpnn.Science, 378(6615):49–56, 2022

Reference 9

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.900557Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.900557Z digest=sha256:2f4d949fd776b013da44b1c3e167952ba271aee7a872a556f0e75d7dcf85d5de

Observation 7959c2b5-b888-47cf-a1d0-a7da8b8380b9 · outbound

This paper cites The foldx web server: an online force field.Nucleic acids research, 33(suppl_2):W382–W388, 2005.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 The foldx web server: an online force field.Nucleic acids research, 33(suppl_2):W382–W388, 2005

Reference 10

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.066756Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:24:59.961471Z digest=sha256:d20d671d3fe3dc70266295ca67b6a1f284c00a597711c90e98daaceb0ab598ef

Observation 043018b5-6dc2-495c-9ad3-953caea0aed6 · outbound

This paper cites Prodigy: a web server for predicting the binding affinity of protein–protein complexes.Bioinformatics, 32(23):3676–3678, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Prodigy: a web server for predicting the binding affinity of protein–protein complexes.Bioinformatics, 32(23):3676–3678, 2016

Reference 11

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.933822Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.071816Z digest=sha256:1f547e8965730cd9b7da27c979197c5162c4380272709a9135e799167b3ab52c

Observation 8758d2f1-0cf4-430d-a8f0-8407e419a225 · outbound

This paper cites Improving de novo protein binder design with deep learning.Nature Communications, 14(1):2625, 2023.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Improving de novo protein binder design with deep learning.Nature Communications, 14(1):2625, 2023

Reference 12

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.782673Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.176255Z digest=sha256:8f8b6936e29741b7a49ba16db7258b8017f16601ec6a19067458911e56b2c014

Observation d93beee5-5c50-4a29-98fd-629b67b1d5d0 · outbound

This paper cites Simulating 500 million years of evolution with a language model.Science, page eads0018, 2025.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Simulating 500 million years of evolution with a language model.Science, page eads0018, 2025

Reference 13

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:00.292247Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:00.292247Z digest=sha256:badd6a9c81d8b9b56b27cf7bc03cc5ec774dd0d21e6ceaf6e34f904ddd15729b

Observation 93dd5d3c-55ff-4fa8-a044-4abfce7b0748 · outbound

This paper cites Design of protein-binding proteins from the target structure alone.Nature, 605(7910):551–560, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Design of protein-binding proteins from the target structure alone.Nature, 605(7910):551–560, 2022

Reference 14

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.625660Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.380172Z digest=sha256:0c129756b3291387db1efdedc2380efbf7553e3fe4f0396224561974dbe88e0d

Observation a482e6dc-606f-4d39-9acf-dd6c338b12cf · outbound

This paper cites Protein data bank (pdb): the single global macromolecular structure archive.Protein crystallography: methods and protocols, pages 627–641, 2017.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein data bank (pdb): the single global macromolecular structure archive.Protein crystallography: methods and protocols, pages 627–641, 2017

Reference 15

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:00.483904Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:00.483904Z digest=sha256:5526366ff7fcbfb4ca45ad9718c863b5b38fb0429e6c9538c66d924bb7558e04

Observation d82560fe-5bc6-43f5-8b51-73e61527de7a · outbound

This paper cites Evaluation of alphafold 3’s protein–protein complexes for predicting binding free energy changes upon mutation.Journal of Chemical Information and Modeling, 64(16):6676–6683, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Evaluation of alphafold 3’s protein–protein complexes for predicting binding free energy changes upon mutation.Journal of Chemical Information and Modeling, 64(16):6676–6683, 2024

Reference 16

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.480896Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.570033Z digest=sha256:fdf93700cef102a6cb6d6816306defacdfef1c0106b3ed88c22a350a058da68d

Observation 75d4b4f5-886c-4339-97ba-5af1d15cb182 · outbound

This paper cites Implementing and assessing an alchemical method for calculating protein–protein binding free energy.Journal of chemical theory and computation, 17(4):2457–2464, 2021.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Implementing and assessing an alchemical method for calculating protein–protein binding free energy.Journal of chemical theory and computation, 17(4):2457–2464, 2021

Reference 17

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.306135Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.680763Z digest=sha256:d88c0b146146a68989f8432443ca2c87e7b6bec26419995569a69c5b32a7f25e

Observation 91039a53-5bc2-4fe9-a420-35369d4e91c4 · outbound

This paper cites Assessment of software methods for estimating protein-protein relative binding affinities.PLoS One, 15(12):e0240573, 2020.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Assessment of software methods for estimating protein-protein relative binding affinities.PLoS One, 15(12):e0240573, 2020

Reference 18

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.149242Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.777704Z digest=sha256:b51db337c8f6a2968069307bfc8ae08682ed36356c1eb43ac8711c4311ff4daa

Observation dafcce08-2111-44b0-bfc9-f326c2fb84f7 · outbound

This paper cites Ab-bind: antibody binding mutational database for computational affinity predictions.Protein Science, 25(2):393–409, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Ab-bind: antibody binding mutational database for computational affinity predictions.Protein Science, 25(2):393–409, 2016

Reference 19

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.031375Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.881330Z digest=sha256:7fd1494b989042892bbab5c33163f374b73c471158643dfcec30a4c59998553e

Observation 8fa354da-1f0b-4201-8f93-3d111cb8273d · outbound

This paper cites Structural and biophysical studies of the human il-7/il-7rα complex.Structure, 17(1):54–65, 2009.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structural and biophysical studies of the human il-7/il-7rα complex.Structure, 17(1):54–65, 2009

Reference 20

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.813132Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:00.985327Z digest=sha256:5ba928a4559e6fb5084710578d8ed707e01a4d4da3095907020f6a5f038634f3

Observation 6027761e-15c3-43e1-b679-ccac8773986f · outbound

This paper cites Structural insight into how bacteria prevent interference between multiple divergent type iv secretion systems.MBio, 6(6):10–1128, 2015.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structural insight into how bacteria prevent interference between multiple divergent type iv secretion systems.MBio, 6(6):10–1128, 2015

Reference 21

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.617586Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.114981Z digest=sha256:af9ad5fd342e88d7f49c45daffb45d1d78f38e0f0032b5758ddb79fc6c5fb758

Observation 2b283110-37d4-47b3-af17-5a2006ab9bdb · outbound

This paper cites Crystal structure of nerve growth factor in complex with the ligand-binding domain of the trka receptor.Nature, 401(6749):184–188, 1999.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Crystal structure of nerve growth factor in complex with the ligand-binding domain of the trka receptor.Nature, 401(6749):184–188, 1999

Reference 22

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.398934Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.225897Z digest=sha256:f4562a43dfbaa1801e6beda7ca563e9e765e35f23379e9b1b9614e3662582103

Observation 19af8a04-effb-446d-8d06-2a511b96cdaf · outbound

This paper cites Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain.Structure, 24(3):469–476, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain.Structure, 24(3):469–476, 2016

Reference 23

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.182896Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.323500Z digest=sha256:54ceae93b9d6e26e8d1329391a9443466698366a466bce8d8ab86e8dd9739061

Observation 581da583-e45d-48d8-8f94-8118101bd9cd · outbound

This paper cites Crystal structures of two fgf-fgfr complexes reveal the determinants of ligand-receptor specificity.Cell, 101(4):413–424, 2000.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Crystal structures of two fgf-fgfr complexes reveal the determinants of ligand-receptor specificity.Cell, 101(4):413–424, 2000

Reference 24

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.907945Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.458861Z digest=sha256:131e053bfd39fea8cf2b90fee8ccfed53a4b4826e7e4b3186aae0ce493b511bd

Observation 02d532cc-eed6-4975-aef1-bb837464db1e · outbound

This paper cites Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Reference 25

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.690388Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.545403Z digest=sha256:dcb9a2be4b68ec5e3d41b78213a57f3eaeda8628ed4cc8d1791dc720612a5168

Observation f38fd8c2-7608-48e4-8728-0065aaa07db3 · outbound

This paper cites Improved prediction of protein-protein interactions using alphafold2.Nature communications, 13(1):1265, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Improved prediction of protein-protein interactions using alphafold2.Nature communications, 13(1):1265, 2022

Reference 26

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:01.630279Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:01.630279Z digest=sha256:f6e3317c8ad3cf2e08b9f57cd247ec0e7de8983083f2b90c2bc1f51bbf469b2c

Observation a735ea7a-3f2e-47c9-b842-941510715375 · outbound

This paper cites Enhanced protein-protein interaction discovery via alphafold-multimer.bioRxiv, pages 2024–02, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Enhanced protein-protein interaction discovery via alphafold-multimer.bioRxiv, pages 2024–02, 2024

Reference 27

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.454214Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.779396Z digest=sha256:97124eaf48f1d75d0608172848bf4376852d8c1079e0d08afa7c9d347bbdf102

Observation 38fced04-eed5-41c5-b3bb-7d3bdb2e2727 · outbound

This paper cites Protein modeling and structure-based drug design.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein modeling and structure-based drug design

Reference 28

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.199951Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-08T06:32:00.761636+00:00.

source=pdf_text observed=2026-08-07T13:25:01.885819Z digest=sha256:b0cd83ca89f58402940672fcd936a1243ad1f81771430ab6fa9e4e19e6be4086

Pith citing papers

No inbound Pith citation observations are available.