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Unlocking Guidance for Discrete State-Space Diffusion and Flow Models
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Generative models on discrete state-spaces have a wide range of potential applications, particularly in the domain of natural sciences. In continuous state-spaces, controllable and flexible generation of samples with desired properties has been realized using guidance on diffusion and flow models. However, these guidance approaches are not readily amenable to discrete state-space models. Consequently, we introduce a general and principled method for applying guidance on such models. Our method depends on leveraging continuous-time Markov processes on discrete state-spaces, which unlocks computational tractability for sampling from a desired guided distribution. We demonstrate the utility of our approach, Discrete Guidance, on a range of applications including guided generation of small-molecules, DNA sequences and protein sequences.
Forward citations
Cited by 6 Pith papers
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A unified diffusion framework with per-modality noise clocks lets one model generate images, text, and tabular data jointly or conditionally in their native spaces.
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On the Design Space of Discrete Diffusion Online Adaptation for Molecular Optimization
Online fine-tuning of discrete diffusion models with complementary acquisition, CVaR shaping, density-entropy debiasing, replay, and validity control finds better molecules under fixed oracle budgets than offline fine...
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IGG, an attention-based reweighting of classifier-free guidance, concentrates guidance on important tokens and modestly improves FID/IS in scale-wise autoregressive image generation.
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