Finite-horizon optimal e-value designs for adaptive single-arm binary trials are constructed via dynamic programming and shown to have competitive operating characteristics with automatic futility indication.
Abraham Wald
2 Pith papers cite this work. Polarity classification is still indexing.
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2026 2verdicts
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The paper defines skew engineering as a path-dependent discipline that reduces downside participation more than upside to improve recovery efficiency and compounding under adverse market regimes.
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Adaptive clinical trials based on design-optimal e-values with automatic curtailment: An application to single-arm trials with binary data
Finite-horizon optimal e-value designs for adaptive single-arm binary trials are constructed via dynamic programming and shown to have competitive operating characteristics with automatic futility indication.
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The Engineering of Skew: A Path-Dependent Framework for Asymmetric Volatility Management
The paper defines skew engineering as a path-dependent discipline that reduces downside participation more than upside to improve recovery efficiency and compounding under adverse market regimes.