A review of fitness landscape navigation in evolution that clarifies terminology around epistasis and ruggedness, compares genotype-phenotype and genotype-fitness levels, proposes a new outcome-based navigability measure, and discusses relaxing static landscape assumptions.
Cano and Joshua L
2 Pith papers cite this work. Polarity classification is still indexing.
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q-bio.PE 2years
2026 2verdicts
UNVERDICTED 2representative citing papers
Emergence bias is defined as the molecular tendency of sequences to be predisposed toward or against gaining new functions upon mutation, synthesized from prior studies on promoters, enhancers, and de novo proteins.
citing papers explorer
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Evolution as fitness landscape navigation: Concepts, Measures, and Emerging Questions
A review of fitness landscape navigation in evolution that clarifies terminology around epistasis and ruggedness, compares genotype-phenotype and genotype-fitness levels, proposes a new outcome-based navigability measure, and discusses relaxing static landscape assumptions.
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Emergence biases in molecular evolution
Emergence bias is defined as the molecular tendency of sequences to be predisposed toward or against gaining new functions upon mutation, synthesized from prior studies on promoters, enhancers, and de novo proteins.