A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.
ph excursions impact cho cell culture performance and antibody n-linked glycosylation.Bioprocess and Biosystems Engineering, 41(12):1731–1741, 2018
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.CB 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.