A novel double Sagnac interferometric configuration with pseudo-thermal light enables high-sensitivity, stable single-shot quantitative phase microscopy and tomography with large FOV and diffraction-limited resolution for biological samples.
High-Fidelity Single-Shot Quantitative Differential Phase Microscopy Using Pseudothermal Sagnac Interferometer
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abstract
In this letter, a high-fidelity single-shot differential quantitative phase microscopy (dQPM) method is presented to effectively image nearly transparent biological samples. The proposed method is based on a common-path Sagnac interferometric configuration, which provides superior temporal phase stability and robustness against environmental disturbances. The proposed system exploits a pseudothermal source to achieve high spatial sensitivity and generate dense interference fringes for effective single-shot differential quantitative phase imaging. The effectiveness of the proposed system is experimentally demonstrated with various samples, including polystyrene microspheres, a USAF phase target, fixed and live HeLa cells, and mouse kidney tissue.
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physics.optics 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
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High-Sensitivity, High-Throughput Double Sagnac Lateral Shearing Quantitative Phase Microscopy and Tomography with Pseudo-Thermal Illumination
A novel double Sagnac interferometric configuration with pseudo-thermal light enables high-sensitivity, stable single-shot quantitative phase microscopy and tomography with large FOV and diffraction-limited resolution for biological samples.