A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.
Metabolic and process engineering to control glycan structures for biopharmaceuticals produced in cultured mammalian cells
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GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.