Composite endpoint hazard ratios are frequently non-constant even when component hazard ratios are constant, with the gap between component effects and baseline hazards driving the non-proportionality and affecting required sample sizes.
D., Claggett B., Tian L
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Non-constant hazard ratios in randomized controlled trials with composite endpoints
Composite endpoint hazard ratios are frequently non-constant even when component hazard ratios are constant, with the gap between component effects and baseline hazards driving the non-proportionality and affecting required sample sizes.