mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.
Error bars denote the standard error across all sequences in the Pareto front
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.BM 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
mRNAutilus: Multi-Objective-Guided Discrete Generation of mRNA with Optimized Therapeutic Properties
mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.