A new benchmarking framework shows virtual cell models overestimate performance on standard tests, drop sharply on unseen contexts and perturbations, and produce inconsistent rankings across metrics.
Perturb-seq: dissecting molecular circuits with scalable single-cell rna profiling of pooled genetic screens.cell, 167(7): 1853–1866
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Benchmarking virtual cell models for in-the-wild perturbation response
A new benchmarking framework shows virtual cell models overestimate performance on standard tests, drop sharply on unseen contexts and perturbations, and produce inconsistent rankings across metrics.