A hybrid agent-based and continuum model for oncolytic virotherapy with immune response shows agreement between discrete and PDE descriptions in 2D but reveals that overly rapid immune activation can reduce therapeutic efficacy due to stochastic effects.
Sheng Guo , The impact of hypoxia on oncolytic virotherapy , Virus Adaptation and Treatment, 3 (2011), p
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A hybrid discrete-continuum modelling approach for the interactions of the immune system with oncolytic viral infections
A hybrid agent-based and continuum model for oncolytic virotherapy with immune response shows agreement between discrete and PDE descriptions in 2D but reveals that overly rapid immune activation can reduce therapeutic efficacy due to stochastic effects.