A nonparametric estimator of the regimen-response curve for stochastic JITAIs on distal outcomes is developed, with weak convergence to a Gaussian process and asymptotic theory for the optimizing policy.
Highly Adaptive Principal Component Regression
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abstract
The Highly Adaptive Lasso (HAL) is a nonparametric regression method that achieves almost dimension-free convergence rates under minimal smoothness assumptions, but its implementation can be computationally prohibitive in high dimensions due to the large design matrix it requires. The Highly Adaptive Ridge (HAR) has been proposed as a related ridge-regularized analogue. Building on both procedures, we introduce the Principal Component Highly Adaptive Lasso (PCHAL) and Principal Component Highly Adaptive Ridge (PCHAR). These estimators use an outcome-blind principal-component reduction of the HAL basis, offering substantial computational gains over HAL while achieving empirical performance comparable to HAL and HAR. We also describe an early-stopped gradient descent variant, which provides a convenient form of smooth spectral regularization without explicitly selecting a hard principal-component cutoff. Finally, we uncover that under special circumstances, the HAL kernel is identical to the covariance function of Brownian motion.
fields
stat.ME 2years
2026 2verdicts
UNVERDICTED 2representative citing papers
TMLE-PR and A-TMLE borrow information from non-subgroup participants in RCTs to improve efficiency of subgroup-specific treatment effect estimation, demonstrated on Black and Asian subgroups in the LEADER trial.
citing papers explorer
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Nonparametric Estimation of Optimal Stochastic Just-In-Time Adaptive Interventions for Distal Outcomes
A nonparametric estimator of the regimen-response curve for stochastic JITAIs on distal outcomes is developed, with weak convergence to a Gaussian process and asymptotic theory for the optimizing policy.
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Improving the Efficiency of Subgroup Analysis in Randomized Controlled Trials with TMLE
TMLE-PR and A-TMLE borrow information from non-subgroup participants in RCTs to improve efficiency of subgroup-specific treatment effect estimation, demonstrated on Black and Asian subgroups in the LEADER trial.