A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.
A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time-to-event.Statistics in Medicine, 30(12):1366–1380
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Joint modelling of time-dependent biomarker variability and time-to-event outcomes, a two-step approach
A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.