Non-collapsible marginal effect measures depend on joint distributions of effect modifiers and prognostic variables, so unadjusted anchored indirect comparisons can be biased even without individual-level treatment effect heterogeneity.
Evidence synthesis for decision making 3: heterogeneity—subgroups, meta- regression, bias, and bias-adjustment.Medical Decision Making2013; 33(5): 618–640
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Transportability of model-based estimands in evidence synthesis
Non-collapsible marginal effect measures depend on joint distributions of effect modifiers and prognostic variables, so unadjusted anchored indirect comparisons can be biased even without individual-level treatment effect heterogeneity.