A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.
Rising serum CA-125 levels within the normal range is strongly associated recurrence risk and survival of ovarian cancer
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Joint modelling of time-dependent biomarker variability and time-to-event outcomes, a two-step approach
A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.