R3LM trains LLMs via two-stage reasoning-then-regression on a new dataset CRE-ReasonBench with mechanistic traces, achieving SOTA enhancer activity prediction across three cell types with interpretable outputs.
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Biological Reasoning-Informed Regression for Interpretable Regulatory DNA Activity Prediction
R3LM trains LLMs via two-stage reasoning-then-regression on a new dataset CRE-ReasonBench with mechanistic traces, achieving SOTA enhancer activity prediction across three cell types with interpretable outputs.