The IF-LOO variance estimator for covariate-adjusted treatment effects with binary outcomes provides appropriate type I error control in simulations, especially for rare events or small samples, with a closed-form implementation.
Cross-Validated Targeted Minimum-Loss-Based Estimation
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Improving Variance Estimation for Covariate Adjustment with Binary Outcomes
The IF-LOO variance estimator for covariate-adjusted treatment effects with binary outcomes provides appropriate type I error control in simulations, especially for rare events or small samples, with a closed-form implementation.